Human IgM and IgG Responses to an Inactivated SARS-CoV-2 Vaccine

被引：13

作者：

Banga Ndzouboukou, Jo-Lewis ^{[1
]}

Zhang, Yan-di ^{[1
]}

Lei, Qing ^{[1
]}

Lin, Xiao-song ^{[1
]}

Yao, Zong-jie ^{[1
]}

Fu, Hui ^{[1
]}

Yuan, Le-yong ^{[2
,3
]}

Fan, Xiong-lin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan 430030, Peoples R China

[2] Southern Univ Sci & Technol Hosp, Dept Clin Lab, Shenzhen 518055, Peoples R China

[3] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China

来源：

CURRENT MEDICAL SCIENCE | 2021年 / 41卷 / 06期

基金：

中国国家自然科学基金;

关键词：

COVID-19; inactivated SARS-CoV-2 vaccine; IgM and IgG antibody responses;

D O I：

10.1007/s11596-021-2461-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates. To explore the influencing factors on vaccine-induced effects, antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were assessed. Methods All subjects aged 18-60 years who did not have SARS-CoV-2 infection at the time of screening from June 19, 2021, to July 02, 2021, were approached for inclusion. All participants received two doses of inactivated SARS-CoV-2 vaccine. Serum IgM and IgG antibodies were detected using a commercial kit after the second dose of vaccination. A positive result was defined as 10 AU/mL or more and a negative result as less than 10 AU/mL. This retrospective study included 97 infection-naive individuals (mean age 35.6 years; 37.1% male, 62.9% female). Results The seropositive rates of IgM and IgG antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1% and 74.2%, respectively. IgG antibody levels were significantly higher than IgM levels (P<0.0001). Sex had no effect on IgM and IgG antibody response after the second dose. The mean anti-IgG level in older persons (> 42 years) was significantly lower than that of younger recipients. There was a significantly lower antibody level at > 42 days compared to that at 0-20 days (P<0.05) and 21-31 days (P<0.05) after the second dose. Conclusion IgG antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals (>18 years), which can be influenced by age and detection time after the second dose of vaccination.

引用

页码：1081 / 1086

页数：6