Human IgM and IgG Responses to an Inactivated SARS-CoV-2 Vaccine

被引:13
|
作者
Banga Ndzouboukou, Jo-Lewis [1 ]
Zhang, Yan-di [1 ]
Lei, Qing [1 ]
Lin, Xiao-song [1 ]
Yao, Zong-jie [1 ]
Fu, Hui [1 ]
Yuan, Le-yong [2 ,3 ]
Fan, Xiong-lin [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan 430030, Peoples R China
[2] Southern Univ Sci & Technol Hosp, Dept Clin Lab, Shenzhen 518055, Peoples R China
[3] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China
基金
中国国家自然科学基金;
关键词
COVID-19; inactivated SARS-CoV-2 vaccine; IgM and IgG antibody responses;
D O I
10.1007/s11596-021-2461-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates. To explore the influencing factors on vaccine-induced effects, antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were assessed. Methods All subjects aged 18-60 years who did not have SARS-CoV-2 infection at the time of screening from June 19, 2021, to July 02, 2021, were approached for inclusion. All participants received two doses of inactivated SARS-CoV-2 vaccine. Serum IgM and IgG antibodies were detected using a commercial kit after the second dose of vaccination. A positive result was defined as 10 AU/mL or more and a negative result as less than 10 AU/mL. This retrospective study included 97 infection-naive individuals (mean age 35.6 years; 37.1% male, 62.9% female). Results The seropositive rates of IgM and IgG antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1% and 74.2%, respectively. IgG antibody levels were significantly higher than IgM levels (P<0.0001). Sex had no effect on IgM and IgG antibody response after the second dose. The mean anti-IgG level in older persons (> 42 years) was significantly lower than that of younger recipients. There was a significantly lower antibody level at > 42 days compared to that at 0-20 days (P<0.05) and 21-31 days (P<0.05) after the second dose. Conclusion IgG antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals (>18 years), which can be influenced by age and detection time after the second dose of vaccination.
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页码:1081 / 1086
页数:6
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