Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

被引：5

作者：

Faustino, Cleidjane Gomes ^{[1
]}

de Medeiros, Fernando Antonio ^{[2
]}

Ribeiro Galardo, Allan Kardec ^{[3
]}

Lobato Rodrigues, Alex Bruno ^{[4
]}

Pena da Costa, Anderson Luiz ^{[1
]}

Martins, Rosany Lopes ^{[4
]}

Brandao, Lethicia Barreto ^{[1
]}

Santos, Lizandra Lima ^{[1
]}

Alves de Medeiros, Marcos Antonio ^{[5
,6
]}

Cantuaria, Patrick de Castro ^{[3
]}

Ferreira Farias, Ana Luzia ^{[1
]}

Cruz, Jader Santos ^{[7
]}

Moreira da Silva de Almeida, Sheylla Susan ^{[1
,4
]}

机构：

[1] Univ Fed Amapa, Lab Pharmacognosy & Phytochem, Postgrad Program Pharmaceut Innovat, Highway Juscelino Kubitschek, BR-68902280 Macapa, Brazil

[2] Univ Fed Amapa, Postgrad Program Hlth Sci, Highway Juscelino Kubitschek, BR-68902280 Macapa, Brazil

[3] Inst Sci & Technol Res State Amapa IEPA, Highway Juscelino Kubitschek, BR-68903419 Macapa, Brazil

[4] Univ Fed Amapa, Lab Pharmacognosy & Phytochem, Postgrad Program Biodivers & Biotechnol Network B, Highway Juscelino Kubitschek, BR-68902280 Macapa, Brazil

[5] Fac Med Sci Paraiba, BR 230,Km 9, BR-58310000 Intermares Cabedelo, Paraiba, Brazil

[6] Nova Esperanca FAMENE Sch Med, BR-58067695 Joao Pessoa, Paraiba, Brazil

[7] Univ Fed Minas Gerais, Dept Biochem & Immunol, Ave Antonio Carlos, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MOLECULES | 2021年 / 26卷 / 21期

关键词：

Protium heptaphyllum; essential oil; Aedes aegypti; biocidal activities; REPELLENTS;

D O I：

10.3390/molecules26216439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work aimed to prepare a nanoemulsion containing the essential oil of the Protium heptaphyllum resin and evaluate its biocidal activities against the different stages of development of the Aedes aegypti mosquito. Ovicide, pupicide, adulticide and repellency assays were performed. The main constituents were p-cymene (27.70%) and alpha-pinene (22.31%). The developed nanoemulsion showed kinetic stability and monomodal distribution at a hydrophilic-lipophilic balance of 14 with a droplet size of 115.56 & PLUSMN; 1.68 nn and a zeta potential of -29.63 & PLUSMN; 3.46 mV. The nanoemulsion showed insecticidal action with LC50 0.404 mu g & BULL;mL(-1) for the ovicidal effect. In the pupicidal test, at the concentration of 160 mu g & BULL;mL(-1), 100% mortality was reached after 24 h. For adulticidal activity, a diagnostic concentration of 200 mu g & BULL;mL(-1) (120 min) was determined. In the repellency test, a concentration of 200 mu g & BULL;mL(-1) during the 180 min of the test showed a protection index of 77.67%. In conclusion, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin can be considered as a promising colloid that can be used to control infectious disease vectors through a wide range of possible modes of applications, probably as this bioactive delivery system may allow the optimal effect of the P. heptaphyllum terpenes in aqueous media and may also induce satisfactory delivery to air interfaces.

引用

页数：10

共 30 条

[11] Mosquitoes and mosquito repellents: A clinician's guide [J].