BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

被引：10

作者：

Adluru, Nagesh ^{[1
]}

Korponay, Cole H. ^{[2
]}

Norton, Derek L. ^{[3
]}

Goldman, Robin I. ^{[4
]}

Davidson, Richard J. ^{[4
,5
,6
]}

机构：

[1] UW Madison, Waisman Ctr, Madison, WI 53703 USA

[2] Harvard Med Sch, McLean Hosp, Boston, MA 02115 USA

[3] UW Madison, Dept Biostat & Med Informat, Madison, WI USA

[4] UW Madison, Ctr Hlth Minds, Madison, WI USA

[5] UW Madison, Dept Psychol, Madison, WI USA

[6] UW Madison, Dept Psychiat, Madison, WI USA

来源：

NEUROCASE | 2020年 / 26卷 / 02期

关键词：

MRI case study; machine learning; long-term meditator; Buddhist monk; INDIVIDUAL BRAINAGE; MEDITATION; AGE; MINDFULNESS;

D O I：

10.1080/13554794.2020.1731553

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates "brain-age" from brain imaging. YMR's brain-aging rate appeared slower than that of controls suggesting early maturation and delayed aging. At 41 years, his brain resembled that of a 33-year-old. Specific regional changes did not differentiate YMR from controls, suggesting that the brain-aging differences may arise from coordinated changes spread throughout the gray matter.

引用

收藏

页码：79 / 90

页数：12

相关论文

共 24 条

[1] Zenmeditation, Length of Telomeres, and the Role of Experiential Avoidance and Compassion [J].

Alda, Marta ;

Puebla-Guedea, Marta ;

Rodero, Baltasar ;

Demarzo, Marcelo ;

Montero-Marin, Jesus ;

Roca, Miquel ;

Garcia-Campayo, Javier .

MINDFULNESS, 2016, 7 (03) :651-659

[2] Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[3] Bias-adjustment in neuroimaging-based brain age frameworks: A robust scheme [J].

Beheshti, Iman ;

Nugent, Scott ;

Potvin, Olivier ;

Duchesne, Simon .

NEUROIMAGE-CLINICAL, 2019, 24

[4]

Casey BJ, 2008, DEV REV, V28, P62, DOI [10.1016/j.dr.2007.08.003, 10.1196/annals.1440.010]

[5] Epigenetic clock analysis in long-term meditators [J].

Chaix, Raphaelle ;

Jesus Alvarez-Lopez, Maria ;

Fagny, Maud ;

Lemee, Laure ;

Regnault, Beatrice ;

Davidson, Richard J. ;

Lutz, Antoine ;

Kaliman, Perla .

PSYCHONEUROENDOCRINOLOGY, 2017, 85 :210-214

[6] Brain age predicts mortality [J].

Cole, J. H. ;

Ritchie, S. J. ;

Bastin, M. E. ;

Hernandez, M. C. Valdes ;

Maniega, S. Munoz ;

Royle, N. ;

Corley, J. ;

Pattie, A. ;

Harris, S. E. ;

Zhang, Q. ;

Wray, N. R. ;

Redmond, P. ;

Marioni, R. E. ;

Starr, J. M. ;

Cox, S. R. ;

Wardlaw, J. M. ;

Sharp, D. J. ;

Deary, I. J. .

MOLECULAR PSYCHIATRY, 2018, 23 (05) :1385-1392

[7] Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres [J].

Epel, Elissa ;

Daubenmier, Jennifer ;

Moskowitz, Judith Tedlie ;

Folkman, Susan ;

Blackburn, Elizabeth .

LONGEVITY, REGENERATION, AND OPTIMAL HEALTH: INTEGRATING EASTERN AND WESTEN PERSPECTIVES, 2009, 1172 :34-53

[8] Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners [J].

Fox, Kieran C. R. ;

Nijeboer, Savannah ;

Dixon, Matthew L. ;

Floman, James L. ;

Ellamil, Melissa ;

Rumak, Samuel P. ;

Sedlmeier, Peter ;

Christoff, Kalina .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2014, 43 :48-73

[9] Changes of individual BrainAGE during the course of the menstrual cycle [J].

Franke, Katja ;

Hagemann, Georg ;

Schleussner, Ekkehard ;

Gaser, Christian .

NEUROIMAGE, 2015, 115 :1-6

[10] Advanced BrainAGE in older adults with type 2 diabetes mellitus [J].

Franke, Katja ;

Gaser, Christian ;

Manor, Brad ;

Novak, Vera .

FRONTIERS IN AGING NEUROSCIENCE, 2013, 5