MK2 balances inflammation and cell death

被引：9
|
作者：
Oberst, Andrew [1 ]
机构：
[1] Univ Washington, Dept Immunol, Seattle, WA 98109 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 10期
关键词：
NF-KAPPA-B; RIPK1; KINASES;
D O I：
10.1038/ncb3619
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.
引用
收藏
页码：1150 / 1152
页数：4
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