MK2 balances inflammation and cell death

被引：9

作者：

Oberst, Andrew ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98109 USA

来源：

NATURE CELL BIOLOGY | 2017年 / 19卷 / 10期

关键词：

NF-KAPPA-B; RIPK1; KINASES;

D O I：

10.1038/ncb3619

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.

引用

页码：1150 / 1152

页数：4

共 15 条

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