Blood vessels engineered from human cells

被引：170
作者：
Poh, M
Boyer, M
Solan, A
Dahl, SLM
Pedrotty, D
Banik, SSR
McKee, JA
Klinger, RY
Counter, CM
Niklason, LE
机构：
[1] Duke Univ, Med Ctr, Dept Anesthesia, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Biomed Engn, Durham, NC 27708 USA
[3] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27708 USA
[4] Univ Pittsburgh, Pittsburgh, PA USA
来源：
LANCET | 2005年 / 365卷 / 9477期
关键词：
D O I：
10.1016/S0140-6736(05)66735-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells. To test this hypothesis, the effectiveness of telomerase expression to extend cellular lifespan was assessed in a model of human vascular tissue engineering. Telomerase expression in vascular cells isolated from elderly patients enabled the successful culture of engineered autologous blood vessels. Engineered vessels may one day provide a source of bypass conduit for patients with atherosclerotic disease.
引用
收藏
页码：2122 / 2124
页数：3
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