Diet and gut microbiome in fatty liver and its associated liver cancer

被引:23
|
作者
Pan, Yasi
Zhang, Xiang
机构
[1] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, CUHK Shenzhen Res Inst, State Key Lab Digest Dis,Inst Digest Dis,Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, CUHK Shenzhen Res Inst, Dept Med & Therapeut,Shatin, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
diet; gut microbiome; HCC; NASH; NONALCOHOLIC STEATOHEPATITIS; INTESTINAL MICROBIOTA; FRUCTOSE CONSUMPTION; INSULIN-RESISTANCE; ADVANCED FIBROSIS; SATURATED FAT; HONG-KONG; DISEASE; OBESITY; ACIDS;
D O I
10.1111/jgh.15713
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide as a consequence of a sedentary lifestyle and overnutrition. NAFLD could progress to non-alcoholic steatohepatitis (NASH), which may further develop to cirrhosis and hepatocellular carcinoma (HCC). The gut microbiome is one of the central regulators in host metabolism. Diet could change human gut microbiome rapidly and reproducibly and modulate several metabolic pathways. Both diet and gut microbiome dysbiosis are associated with NAFLD and its related HCC (NAFLD-HCC). Dietary cholesterol, fiber, fat, or carbohydrate could change the microbiome composition to contribute to the development of NASH and NAFLD-HCC. Hence, identification of elements of the gut-liver axis that are primarily damaged in NASH and NAFLD-HCC offers new possibility for therapeutic intervention. In this review, the roles of gut microbiome and microbial metabolites in the development and progression of NAFLD and NAFLD-HCC are first discussed. The impacts of different diet compositions including cholesterol, fiber, fat, and sugar on the gut microbiome that leads to predisposition to NASH and NAFLD-HCC are also explored. We summarized the article by discussing potential therapeutic implication of diet and microbiome modulation in fatty liver and liver cancer.
引用
收藏
页码:7 / 14
页数:8
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