The multifaceted involvement of exosomes in tumor progression: Induction and inhibition

被引：18

作者：

Gu, Wen-Jie ^{[1
]}

Shen, Yi-Wen ^{[1
]}

Zhang, Li-Jun ^{[1
]}

Zhang, Hong ^{[1
]}

Nagle, Dale G. ^{[1
,2
,3
]}

Luan, Xin ^{[1
]}

Liu, San-Hong ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China

[2] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, University, MS 38677 USA

来源：

MEDCOMM | 2021年 / 2卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biomarker; cancer; drug delivery; exosome; microRNAs; METASTATIC NICHE FORMATION; CELL-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; MESENCHYMAL TRANSITION; CANCER; PROMOTE; ANGIOGENESIS; CHEMORESISTANCE; MICRORNAS; BIOLOGY;

D O I：

10.1002/mco2.49

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As key performers in intercellular communication, exosomes released by tumor cells play an important role in cancer development, including angiogenesis, cancer-associated fibroblasts activation, epithelial-mesenchymal transformation (EMT), immune escape, and pre-metastatic niche formation. Meanwhile, other cells in tumor microenvironment (TME) can secrete exosomes and facilitate tumor progression. Elucidating mechanisms regarding these processes may offer perspectives for exosome-based antitumor strategies. In this review, we mainly introduce the versatile roles of tumor or stromal cell derived exosomes in cancer development, with a particular focus on the biological capabilities and functionalities of their diverse contents, such as miRNAs, lncRNAs, and circRNAs. The potential clinical application of exosomes as biomarkers in cancer diagnosis and prognosis is also discussed. Finally, the current antitumor strategies based on exosomes in immunotherapy and targeted delivery for chemotherapeutic or biological agents are summarized.

引用

页码：297 / 314

页数：18

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