Sulfinates and thiocyanates triggered 6-endo cyclization of o-alkynylisocyanobenzenes

被引：21

作者：

Khaikate, Onnicha

Meesin, Jatuporn

Pohmakotr, Manat

Reutrakul, Vichai

Leowanawat, Pawaret

Soorukram, Darunee

Kuhakarn, Chutima ^{[1
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Rama 6 Rd, Bangkok 10400, Thailand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 44期

关键词：

QUINOLINE N-OXIDES; ONE-POT SYNTHESIS; INTRAMOLECULAR CYCLIZATION; CATALYZED SULFONYLATION; MEDIATED SULFONYLATION; ISOCYANIDE INSERTION; RADICAL CYCLIZATION; C2; SULFONYLATION; SULFUR-DIOXIDE; INHIBITORS;

D O I：

10.1039/c8ob02338g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diverse 2-sulfonyl- and 2-thiocyanato-3-substituted quinolines were synthesized from o-alkynylisocyanobenzenes by nucleophilic addition of the respective sulfinate sodium salts and ammonium thiocyanate to the isocyanide moiety followed by cyclization. The salient features of the methodology include metal-free, ambient temperature and mild reaction conditions, ease of reagent handling, and broad functional group tolerance.

引用

收藏

页码：8553 / 8558

页数：6

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