Tetrabutylammonium Fluoride (TBAF) Catalysed Synthesis of 2-Arylbenzimidazole in Water under Ultrasound Irradiation

被引：22
|
作者：
Joshi, Ratnadeep S. [1 ]
Mandhane, Priyanka G. [1 ]
Dabhade, Sanjay K. [1 ]
Gill, Charansingh H. [1 ]
机构：
[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, MS, India
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2010年 / 57卷 / 6B期
关键词：
Tetrabutylammonium fluoride (TBAF); Water; 2-Benzimidazole; Ultrasonication; Green synthesis; DNA-BINDING; BENZIMIDAZOLES; INHIBITORS; HOECHST-33258; NITROBENZENE; PHARMACOLOGY; SPECIFICITY; OMEPRAZOLE; MICROWAVE; BASE;
D O I：
10.1002/jccs.201000181
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One-pot multistep reactions involving a new environmentally friendly catalytic procedure have been developed for the synthesis of benzimidazole. The reaction of the substituted aldehyde with o-phenylenediamine in water under ultrasonic irradiation at ambient temperature for appropriate time using 5 mol% of TBAF furnish the desired product in good to excellent yield. The process is green, mild, inexpensive, excellent chemo selectivity, and excellent yields are the main advantages of this procedure.
引用
收藏
页码：1227 / 1231
页数：5
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