Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis

被引：12

作者：

Sun, Wen-Xia ^{[1
]}

Chen, Ying-Hua ^{[2
]}

Liu, Zhi-Zhong ^{[3
]}

Xie, Jian-Jun ^{[3
]}

Wang, Wei ^{[3
]}

Du, Ya-Ping ^{[3
]}

Chen, Yu ^{[3
]}

Shen, Xu-Liang ^{[4
]}

He, Xiao-Feng ^{[5
]}

Wu, Li-Xia ^{[5
]}

Wei, Wu ^{[4
]}

Zhang, Lin ^{[2
]}

机构：

[1] Changzhi Med Coll, Dept Gynecol, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China

[2] Southern Med Univ, Div Histol & Embryol, Sch Basic Med Sci, Guangzhou 510515, Guangdong, Peoples R China

[3] Second Peoples Hosp Zhuhai, Dept Gastroenterol, Zhuhai 519000, Guangdong, Peoples R China

[4] Changzhi Med Coll, Dept Hematol, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China

[5] Changzhi Med Coll, Dept Res, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China

来源：

MOLECULAR GENETICS AND GENOMICS | 2015年 / 290卷 / 02期

关键词：

CYP1A2; Polymorphism; Cancer; Susceptibility; Meta-analysis; CARCINOGEN-METABOLIZING ENZYMES; N-ACETYLTRANSFERASE GENES; HETEROCYCLIC AMINE LEVELS; COLORECTAL-CANCER; LUNG-CANCER; CIGARETTE-SMOKING; BLADDER-CANCER; RED MEAT; CYTOCHROME-P450; 1A2; ESTROGEN METABOLISM;

D O I：

10.1007/s00438-014-0956-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.

引用

页码：709 / 725

页数：17

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