Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis

被引:12
作者
Sun, Wen-Xia [1 ]
Chen, Ying-Hua [2 ]
Liu, Zhi-Zhong [3 ]
Xie, Jian-Jun [3 ]
Wang, Wei [3 ]
Du, Ya-Ping [3 ]
Chen, Yu [3 ]
Shen, Xu-Liang [4 ]
He, Xiao-Feng [5 ]
Wu, Li-Xia [5 ]
Wei, Wu [4 ]
Zhang, Lin [2 ]
机构
[1] Changzhi Med Coll, Dept Gynecol, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China
[2] Southern Med Univ, Div Histol & Embryol, Sch Basic Med Sci, Guangzhou 510515, Guangdong, Peoples R China
[3] Second Peoples Hosp Zhuhai, Dept Gastroenterol, Zhuhai 519000, Guangdong, Peoples R China
[4] Changzhi Med Coll, Dept Hematol, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China
[5] Changzhi Med Coll, Dept Res, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China
关键词
CYP1A2; Polymorphism; Cancer; Susceptibility; Meta-analysis; CARCINOGEN-METABOLIZING ENZYMES; N-ACETYLTRANSFERASE GENES; HETEROCYCLIC AMINE LEVELS; COLORECTAL-CANCER; LUNG-CANCER; CIGARETTE-SMOKING; BLADDER-CANCER; RED MEAT; CYTOCHROME-P450; 1A2; ESTROGEN METABOLISM;
D O I
10.1007/s00438-014-0956-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
引用
收藏
页码:709 / 725
页数:17
相关论文
共 92 条
[1]   Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition [J].
Agudo, Antonio ;
Sala, Nuria ;
Pera, Guillem ;
Capella, Gabriel ;
Berenguer, Antonio ;
Garcia, Nadia ;
Palli, Domenico ;
Boeing, Heiner ;
Del Giudice, Giuseppe ;
Saieva, Calogero ;
Carneiro, Fatima ;
Berrino, Franco ;
Sacerdote, Carlotta ;
Tumino, Rosario ;
Panico, Salvatore ;
Berglund, Goran ;
Siman, Henrik ;
Stenling, Roger ;
Hallmans, Goran ;
Martinez, Carmen ;
Bilbao, Roberto ;
Barricarte, Aurelio ;
Navarro, Carmen ;
Quiros, Jose R. ;
Allen, Naomi ;
Key, Tim ;
Bingham, Sheila ;
Khaw, Kay-Tee ;
Linseisen, Jakob ;
Nagel, Gabriele ;
Overvad, Kim ;
Tjonneland, Anne ;
Olsen, Anja ;
Bueno-de-Mesquita, H. Bas ;
Boshuizen, Hendriek C. ;
Peeters, Petra H. ;
Numans, Mattijs E. ;
Clavel-Chapelon, Francoise ;
Boutron-Ruault, Marie-Christine ;
Trichopoulou, Antonia ;
Lund, Eiliv ;
Offerhaus, Johan ;
Jenab, Mazda ;
Ferrari, Pietro ;
Norat, Teresa ;
Riboli, Elio ;
Gonzalez, Carlos A. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (12) :2427-2434
[2]   CYP1A1/2 Haplotypes and Lung Cancer and Assessment of Confounding by Population Stratification [J].
Aldrich, Melinda C. ;
Selvin, Steve ;
Hansen, Helen M. ;
Barcellos, Lisa F. ;
Wrensch, Margaret R. ;
Sison, Jennette D. ;
Kelsey, Karl T. ;
Buffler, Patricia A. ;
Quesenberry, Charles P., Jr. ;
Seldin, Michael F. ;
Wiencke, John K. .
CANCER RESEARCH, 2009, 69 (06) :2340-2348
[3]   CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population [J].
Altayli, Ertan ;
Gunes, Sezgin ;
Yilmaz, Ali Faik ;
Goktas, Serdar ;
Bek, Yuksel .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2009, 41 (02) :259-266
[4]  
[Anonymous], ENDOCR RELAT CANC
[5]  
[Anonymous], 1997, LANCET
[6]   Role of CYP1A2 polymorphisms in breast cancer risk in women [J].
Ayari, Imene ;
Fedeli, Ugo ;
Saguem, Saad ;
Hidar, Samir ;
Khlifi, Saida ;
Pavanello, Sofia .
MOLECULAR MEDICINE REPORTS, 2013, 7 (01) :280-286
[7]   CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population [J].
B'chir, Fatma ;
Pavanello, Sofia ;
Knani, Jalel ;
Boughattas, Sami ;
Arnaud, Maurice J. ;
Saguem, Saad .
LIFE SCIENCES, 2009, 84 (21-22) :779-784
[8]   Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans [J].
Bae, Sun-Young ;
Choi, Sun-Keun ;
Kim, Kyung-Rae ;
Park, Chang-Shin ;
Lee, Sung-Keun ;
Roh, Hyung-Keun ;
Shin, Dong-Woon ;
Pie, Jae-Eun ;
Woo, Ze-Hong ;
Kang, Ju-Hee .
CANCER SCIENCE, 2006, 97 (08) :774-779
[9]   Genes of detoxification are important modulators of hereditary medullary thyroid carcinoma risk [J].
Barbieri, R. B. ;
Bufalo, N. E. ;
Cunha, L. L. ;
Assumpcao, L. V. M. ;
Maciel, R. M. B. ;
Cerutti, J. M. ;
Ward, L. S. .
CLINICAL ENDOCRINOLOGY, 2013, 79 (02) :288-293
[10]   Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma [J].
Barbieri, R. B. ;
Bufalo, N. E. ;
Secolin, R. ;
Silva, A. C. N. ;
Assumpcao, L. V. M. ;
Maciel, R. M. B. ;
Cerutti, J. M. ;
Ward, L. S. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 166 (02) :241-245