A new approach for anemia in kidney disease

被引:2
作者
Messa, Piergiorgio [1 ]
Cappellini, Maria Domenica [2 ]
机构
[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Nephrol Dialysis & Renal Transplant Unit, Milan, Italy
[2] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy
关键词
Kidney disease; Anemia; Erythropoietin; Prolyl hydroxylase domain (PHD) dioxygenases; HYDROXYLASE INHIBITOR FG-4592; ROXADUSTAT FG-4592; EPOETIN-ALPHA; HYPOXIA; PHARMACODYNAMICS; PHASE-2;
D O I
10.1016/j.ejim.2019.10.035
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1 / 3
页数:3
相关论文
共 28 条
[1]   Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients [J].
Besarab, Anatole ;
Chernyayskaya, Elena ;
Motylev, Igor ;
Shutov, Evgeny ;
Kumbar, Lalathaksha M. ;
Gurevich, Konstantin ;
Chan, Daniel Tak Mao ;
Leong, Robert ;
Poole, Lona ;
Zhong, Ming ;
Saikali, Khalil G. ;
Franco, Marietta ;
Hemmerich, Stefan ;
Kin-Hung Peony Yu ;
Neff, Thomas B. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (04) :1225-1233
[2]   Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients [J].
Besarab, Anatole ;
Provenzano, Robert ;
Hertel, Joachim ;
Zabaneh, Raja ;
Klaus, Stephen J. ;
Lee, Tyson ;
Leong, Robert ;
Hemmerich, Stefan ;
Yu, Kin-Hung Peony ;
Neff, Thomas B. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30 (10) :1665-1673
[3]   Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis [J].
Chen, N. ;
Hao, C. ;
Peng, X. ;
Lin, H. ;
Yin, A. ;
Hao, L. ;
Tao, Y. ;
Liang, X. ;
Liu, Z. ;
Xing, C. ;
Chen, J. ;
Luo, L. ;
Zuo, L. ;
Liao, Y. ;
Liu, B-C ;
Leong, R. ;
Wang, C. ;
Liu, C. ;
Neff, T. ;
Szczech, L. ;
Yu, K-H P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (11) :1001-1010
[4]   Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis [J].
Chen, N. ;
Hao, C. ;
Liu, B-C ;
Lin, H. ;
Wang, Caili ;
Xing, C. ;
Liang, X. ;
Jiang, G. ;
Liu, Zhengrong ;
Li, X. ;
Zuo, L. ;
Luo, L. ;
Wang, J. ;
Zhao, M. ;
Liu, Zhihong ;
Cai, G-Y ;
Hao, L. ;
Leong, R. ;
Wang, Chunrong ;
Liu, C. ;
Neff, T. ;
Szczech, L. ;
Yu, K-H P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (11) :1011-1022
[5]   Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China [J].
Chen, Nan ;
Qian, Jiaqi ;
Chen, Jianghua ;
Yu, Xueqing ;
Mei, Changlin ;
Hao, Chuanming ;
Jiang, Gengru ;
Lin, Hongli ;
Zhang, Xinzhou ;
Zuo, Li ;
He, Qiang ;
Fu, Ping ;
Li, Xuemei ;
Ni, Dalvin ;
Hemmerich, Stefan ;
Liu, Cameron ;
Szczech, Lynda ;
Besarab, Anatole ;
Neff, Thomas B. ;
Yu, Kin-Hung Peony ;
Valone, Frank H. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2017, 32 (08) :1373-1386
[6]   Roxadustat: another drug that causes pulmonary hypertension? Report of first human case [J].
Cygulska, Kamila ;
Wejner-Mik, Paulina ;
Plewka, Michal ;
Figiel, Lukasz ;
Chrzanowski, Lukasz ;
Kasprzak, Jaroslaw D. .
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, 2019, 129 (05) :344-345
[7]   Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease [J].
Del Vecchio, Lucia ;
Locatelli, Francesco .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (07) :613-621
[8]   Normalization of hemoglobin level in patients with chronic kidney disease and anemia [J].
Drueke, Tilman B. ;
Locatelli, Francesco ;
Clyne, Naomi ;
Eckardt, Kai-Uwe ;
Macdougall, Iain C. ;
Tsakiris, Dimitrios ;
Burger, Hans-Ulrich ;
Scherhag, Armin .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (20) :2071-2084
[9]   Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer [J].
Fujimoto, Tara N. ;
Colbert, Lauren E. ;
Huang, Yanqing ;
Molkentine, Jessica M. ;
Deorukhkar, Amit ;
Baseler, Laura ;
Bonilla, Marimar de la Cruz ;
Yu, Meifang ;
Lin, Daniel ;
Gupta, Sonal ;
Cabeceiras, Peter K. ;
Kingsley, Charles, V ;
Tailor, Ramesh C. ;
Sawakuchi, Gabriel O. ;
Koay, Eugene J. ;
Piwnica-Worms, Helen ;
Maitra, Anirban ;
Taniguchi, Cullen M. .
CANCER RESEARCH, 2019, 79 (09) :2327-2338
[10]   Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor [J].
Groenendaal-van de Meent, Dorien ;
den Adel, Martin ;
Noukens, Jan ;
Rijnders, Sanne ;
Krebs-Brown, Axel ;
Mateva, Lyudmila ;
Alexiev, Assen ;
Schaddelee, Marloes .
CLINICAL DRUG INVESTIGATION, 2016, 36 (09) :743-751