Quorum Sensing Inhibitors against Chromobacterium violaceum CV026 Derived from an Actinomycete Metabolite Library

被引：9

作者：

Ohta, Toshiko ^{[1
]}

Fukumoto, Atsushi ^{[1
]}

Iizaka, Yohei ^{[1
]}

Kato, Fumio ^{[1
]}

Koyama, Yasumasa ^{[1
]}

Anzai, Yojiro ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2020年 / 43卷 / 01期

关键词：

quorum sensing inhibitor; Pseudomonas aeruginosa; actinomycete metabolite library; STREPTOMYCES-LUTEORETICULI KATOH; PSEUDOMONAS-AERUGINOSA; BIOSYNTHESIS; VIRULENCE; SERRATIA; ANTIBIOTICS; PRODIGIOSIN; CARBAPENEM; MULTIPLE;

D O I：

10.1248/bpb.b19-00564

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Quorum sensing (QS) is a microbial signaling system that regulates the expression of many virulence genes. Herein, we studied five compounds-No. 1: (E)-2-methyl-3- (4-nitro-phenyl)-acrylaldehyde; No. 29-2: pimprinine [5-(1H-indo1-3-yl)-2-methyloxazole]; No. 48: (2E,4E)-2-methyl-5-phenyl-2,4-pentadienoic acid; No. 74: (3E,5E)-5-methyl-6-(4-nitrophenyl)-hexa-3,5-dien-2-ol; and No. 130: methyphenazine-1-carboxylate-derived from an actinomycete metabolite library. These compounds were confirmed to be QS inhibitors that reduced violacein production in Chromobacterium violaceum CV026. Additionally, compounds No. 1, No. 74, and No. 130 significantly reduced fluorescent pigment production in Pseudomonas aeruginosa ATCC 27853.

引用

页码：179 / 183

页数：5

共 30 条

[1] Quorum sensing in bacterial virulence
Antunes, L. Caetano M.
Ferreira, Rosana B. R.
Buckner, Michelle M. C.
Finlay, B. Brett
[J]. MICROBIOLOGY-SGM, 2010, 156 : 2271 - 2282
[2] The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia
Baldwin, A
Sokol, PA
Parkhill, J
Mahenthiralingam, E
[J]. INFECTION AND IMMUNITY, 2004, 72 (03) : 1537 - 1547
[3] Bacterially speaking
Bassler, BL
Losick, R
[J]. CELL, 2006, 125 (02) : 237 - 246
[4] SYNTHESIS OF MULTIPLE EXOPRODUCTS IN PSEUDOMONAS-AERUGINOSA IS UNDER THE CONTROL OF RHLR-RHLI, ANOTHER SET OF REGULATORS IN STRAIN PAO1 WITH HOMOLOGY TO THE AUTOINDUCER-RESPONSIVE LUXR-LUXI FAMILY
BRINT, JM
OHMAN, DE
[J]. JOURNAL OF BACTERIOLOGY, 1995, 177 (24) : 7155 - 7163
[5] The biology and future prospects of antivirulence therapies
Cegelski, Lynette
Marshall, Garland R.
Eldridge, Gary R.
Hultgren, Scott J.
[J]. NATURE REVIEWS MICROBIOLOGY, 2008, 6 (01) : 17 - 27
[6] Involvement of N-acyl-L-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens
Eberl, L
Winson, MK
Sternberg, C
Stewart, GSAB
Christiansen, G
Chhabra, SR
Bycroft, B
Williams, P
Molin, S
Givskov, M
[J]. MOLECULAR MICROBIOLOGY, 1996, 20 (01) : 127 - 136
[7] Falcao Juliana P, 2004, Curr Issues Intest Microbiol, V5, P9
[8] Distal and proximal promoters co-regulate pqsR expression in Pseudomonas aeruginosa
Farrow, John M., III
Pesci, Everett C.
[J]. MOLECULAR MICROBIOLOGY, 2017, 104 (01) : 78 - 91
[9] Quorum sensing: A novel target for anti-infective therapy
Finch, RG
Pritchard, DI
Bycroft, BW
Williams, P
Stewart, GSAB
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) : 569 - 571
[10] Biosynthesis of tripyrrole and β-lactam secondary metabolites in Serratia:: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production
Fineran, PC
Slater, H
Everson, L
Hughes, K
Salmond, GPC
[J]. MOLECULAR MICROBIOLOGY, 2005, 56 (06) : 1495 - 1517

← 1 2 3 →