Saturated Fatty Acids Modulate Autophagy's Proteins in the Hypothalamus

被引:46
|
作者
Portovedo, Mariana [1 ,2 ]
Ignacio-Souza, Leticia M. [3 ]
Bombassaro, Bruna [2 ]
Coope, Andressa [2 ]
Reginato, Andressa [1 ,2 ]
Razolli, Daniela S. [2 ]
Torsoni, Marcio A. [1 ,2 ]
Torsoni, Adriana S. [1 ,2 ]
Leal, Raquel F. [2 ]
Velloso, Licio A. [2 ]
Milanski, Marciane [1 ,2 ]
机构
[1] Univ Estadual Campinas, UNICAMP, Fac Sci Appl, Limeira, Brazil
[2] Univ Estadual Campinas, UNICAMP, Obes & Comorbid Res Ctr, Campinas, SP, Brazil
[3] Univ Fed Mato Grosso, Fac Nutr, Cuiaba, Brazil
来源
PLOS ONE | 2015年 / 10卷 / 03期
基金
巴西圣保罗研究基金会;
关键词
N-TERMINAL KINASE; BETA/NF-KAPPA-B; INSULIN-RESISTANCE; ENERGY-METABOLISM; CELL-DEATH; ER STRESS; OBESITY; BRAIN; MECHANISM; NEURONS;
D O I
10.1371/journal.pone.0119850
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and content of autophagic proteins in animal with obesity induced by 8 or 16 weeks high fat diet to induce obesity and in response to intracerebroventricular injections of palmitic acid. The results showed that chronic exposure to a high fat diet leads to an increased expression of inflammatory markers and downregulation of autophagic proteins. In obese mice, autophagic induction leads to the downregulation of proteins, such as JNK and Bax, which are involved in the stress pathways. In neuron cell-line, palmitate has a direct effect on autophagy even without inflammatory activity. Understanding the cellular and molecular bases of overnutrition is essential for identifying new diagnostic and therapeutic targets for obesity.
引用
收藏
页数:16
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