Plasma long non-coding RNA HOTAIR as a potential biomarker for gastric cancer

被引：52
作者：
Elsayed, Eman T. [1 ]
Salem, Perihan E. [2 ]
Darwish, Azaa M. [3 ]
Fayed, Haytham M. [4 ]
机构：
[1] Alexandria Univ, Clin Pathol Dept, Alexandria, Egypt
[2] Alexandria Univ, Internal Med Dept, Alexandria, Egypt
[3] Alexandria Univ, Oncol Dept, Alexandria, Egypt
[4] Alexandria Univ, Surg Dept, Alexandria, Egypt
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2018年 / 33卷 / 04期
关键词：
HOTAIR; long non-coding RNA; gastric cancer; non-invasive biomarker; EPITHELIAL-MESENCHYMAL TRANSITION; INHIBITS PROLIFERATION; CLINICAL-SIGNIFICANCE; EXPRESSION; METASTASIS; INVASION; MICRORNAS; CARCINOMA; RECEPTOR; LNCRNAS;
D O I：
10.1177/1724600818760244
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Long non-coding RNAs (lncRNAs) Hox transcript antisense intergenic RNA (HOTAIR) has been suggested to be implicated in gastric cancer tumorigenesis and progression; however, little is known about the role of the plasma HOTAIR in gastric cancer diagnosis and prognosis. Objective: The current study was aimed at investigating the clinical relevance of plasma long non-coding HOTAIR as a non-invasive diagnostic biomarker in gastric cancer. Methods: Plasma HOTAIR expression was measured in 50 patients with newly diagnosed gastric cancer and 50 age- and sex-matched healthy controls using quantitative reverse transcription polymerase chain reaction. Results: Plasma level of HOTAIR was significantly higher in gastric cancer patients compared with healthy controls (P < 0.001). By using receiver operating characteristic curve analysis, it was found that plasma HOTAIR could diagnose gastric cancer with 88% sensitivity and 84% specificity. Furthermore, increased HOTAIR expression was associated with advanced tumor stages, higher grades, and metastasis. Conclusion: Plasma HOTAIR might serve as a potential non-invasive biomarker for diagnosis of gastric cancer.
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收藏
页码：528 / 533
页数：6
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