Preclinical Studies and Clinical Trials with Mesenchymal Stem Cell for De-myelinating Diseases: A Systematic Review

被引：4

作者：

Esmaeilizade, Zahra ^{[1
]}

Mohammadi, Bahar ^{[1
]}

Omrani, Mir Davood ^{[1
]}

Ghaderian, Sayyed Mohammad Hossein ^{[1
]}

Rajabibazl, Masoumeh ^{[2
]}

Fazeli, Zahra ^{[1
,3
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Fac Med, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2021年 / 16卷 / 08期

关键词：

Mesenchymal stem cells; multiple sclerosis; cellular therapy; remyelination; stabilization; transplantation; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROGRESSIVE MULTIPLE-SCLEROSIS; CENTRAL-NERVOUS-SYSTEM; MARROW STROMAL CELLS; BONE-MARROW; NEURAL PROGENITORS; SPINAL-CORD; MODIFYING TREATMENTS; FUNCTIONAL RECOVERY; EXPERIMENTAL-MODEL;

D O I：

10.2174/1574888X16666210208162318

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Aim: Different studies have been performed to investigate stem cell administration as a promising tool for recovery of injured tissue in multiple sclerosis (MS), the most common demyelinating disease. Methods: In the present systematic review, the electronic databases of PubMed and ScienceDirect were searched to screen English language studies published until April 2020. Results: The results obtained from experimental autoimmune encephalomyelitis (EAE) animals revealed that modified mesenchymal stem cells (MSCs) transplantation was associated with remyelination, inflammation suppression and oligodendrocyte precursor cells regeneration. Clinical trials indicated that 70% of the patients with MS showed disease stabilization following MSCs administration. Conclusion: Although MSC therapy has showed to be effective in the improvement of some patients with MS, designing larger placebo-controlled clinical trials with MSCs expressing immune-regulators or MSCs-exosomes may provide a novel viewpoint in the treatment of MS.

引用

页码：1005 / 1017

页数：13

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