BLOCKADE OF CENTRAL NICOTINE ACETYLCHOLINE RECEPTOR SIGNALING ATTENUATE GHRELIN-INDUCED FOOD INTAKE IN RODENTS

被引：63

作者：

Dickson, S. L. ^{[1
]}

Hrabovszky, E. ^{[2
]}

Hansson, C. ^{[1
]}

Jerlhag, E. ^{[3
]}

Alvarez-Crespo, M. ^{[1
]}

Skibicka, K. P. ^{[1
]}

Molnar, C. S. ^{[2
]}

Liposits, Z. ^{[2
]}

Engel, J. A. ^{[3
]}

Egecioglu, E. ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, SE-40530 Gothenburg, Sweden

[2] Hungarian Acad Sci, Inst Expt Med, Lab Endocrine Neurobiol, H-1083 Budapest, Hungary

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Pharmacol, SE-40530 Gothenburg, Sweden

来源：

NEUROSCIENCE | 2010年 / 171卷 / 04期

基金：

英国医学研究理事会; 美国国家科学基金会;

关键词：

GHS-R1A; dopamine; appetite; reward seeking; CPP; palatable food; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; STIMULATES LOCOMOTOR-ACTIVITY; CHOLINERGIC NEURONS; DOPAMINE-OVERFLOW; MESSENGER-RNA; BRAIN REWARD; RAT; AREAS; ACCUMBENS; MECAMYLAMINE;

D O I：

10.1016/j.neuroscience.2010.10.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Here we sought to determine whether ghrelin s central effects on food intake can be interrupted by nicotine acetylcholine receptor (nAChR) blockade Ghrelin regulates mesolimbic dopamine neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens partly via cholinergic VTA afferents originating in the laterodorsal tegmental area (LDTg) Given that these cholinergic projections to the VTA have been implicated in natural as well as drug-induced reinforcement, we sought to investigate the role of cholinergic signaling in ghrelin induced food intake as well as fasting-induced food intake, for which endogenous ghrelin has been implicated We found that i p treatment with the non selective centrally active nAChR antagonist, mecamylamine decreased fasting induced food intake in both mice and rats Moreover, central administration of mecamylamine decreased fasting-induced food intake in rats I c v ghrelin induced food intake was suppressed by mecamylamine i p but not by hexamethonium i p, a peripheral nAChR antagonist Furthermore, mecamylamine i p blocked food intake following ghrelin injection into the VTA Expression of the ghrelin receptor, the growth hormone secretagogue receptor 1A, was found to co-localize with choline acetyltransferase, a marker of cholinergic neurons, in the LDTg Finally, mecamylamine treatment i p decreased the ability of palatable food to condition a place preference These data suggest that ghrelin induced food intake is partly mediated via nAChRs and that nicotinic blockade decreases the rewarding properties of food (C) 2010 IBRO Published by Elsevier Ltd All rights reserved

引用

页码：1180 / 1186

页数：7

共 37 条

[1] Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite [J].