History, evolution and classification of CRISPR-Cas associated systems

被引:21
作者
Agarwal, Nisheeth [1 ]
Gupta, Radhika [2 ]
机构
[1] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, Faridabad, Haryana, India
[2] Univ Delhi, Daulat Ram Coll, Delhi, India
来源
REPROGRAMMING THE GENOME: APPLICATIONS OF CRISPR-CAS IN NON-MAMMALIAN SYSTEMS, PT A | 2021年 / 179卷
关键词
EXTRAGENIC PALINDROMIC SEQUENCES; HORIZONTAL GENE-TRANSFER; DNA CLEAVAGE; TARGET DNA; NUCLEOTIDE-SEQUENCE; SPACER ACQUISITION; HALOFERAX-MEDITERRANEI; ACQUIRED-RESISTANCE; ESCHERICHIA-COLI; STRUCTURAL BASIS;
D O I
10.1016/bs.pmbts.2020.12.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This chapter provides a detailed description of the history of CRISPR-Cas and its evolution into one of the most efficient genome-editing strategies. The chapter begins by providing information on early findings that were critical in deciphering the role of CRISPR-Cas associated systems in prokaryotes. It then describes how CRISPR-Cas had been evolved into an efficient genome-editing strategy. In the subsequent section, latest developments in the genome-editing approaches based on CRISPR-Cas are discussed. The chapter ends with the recent classification and possible evolution of CRISPR-Cas systems.
引用
收藏
页码:11 / 76
页数:66
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