History, evolution and classification of CRISPR-Cas associated systems

被引：20

作者：

Agarwal, Nisheeth ^{[1
]}

Gupta, Radhika ^{[2
]}

机构：

[1] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, Faridabad, Haryana, India

[2] Univ Delhi, Daulat Ram Coll, Delhi, India

来源：

REPROGRAMMING THE GENOME: APPLICATIONS OF CRISPR-CAS IN NON-MAMMALIAN SYSTEMS, PT A | 2021年 / 179卷

关键词：

EXTRAGENIC PALINDROMIC SEQUENCES; HORIZONTAL GENE-TRANSFER; DNA CLEAVAGE; TARGET DNA; NUCLEOTIDE-SEQUENCE; SPACER ACQUISITION; HALOFERAX-MEDITERRANEI; ACQUIRED-RESISTANCE; ESCHERICHIA-COLI; STRUCTURAL BASIS;

D O I：

10.1016/bs.pmbts.2020.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This chapter provides a detailed description of the history of CRISPR-Cas and its evolution into one of the most efficient genome-editing strategies. The chapter begins by providing information on early findings that were critical in deciphering the role of CRISPR-Cas associated systems in prokaryotes. It then describes how CRISPR-Cas had been evolved into an efficient genome-editing strategy. In the subsequent section, latest developments in the genome-editing approaches based on CRISPR-Cas are discussed. The chapter ends with the recent classification and possible evolution of CRISPR-Cas systems.

引用

页码：11 / 76

页数：66

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