Glioblastoma Multiforme and its Cell Interruption

被引：2
作者：
Bhattacharya, Sankha [1 ]
机构：
[1] ISF Coll Pharm, Dept Pharmaceut, GT Rd NH-95, Moga 142001, Punjab, India
来源：
CURRENT CANCER THERAPY REVIEWS | 2021年 / 17卷 / 02期
关键词：
Glioblastoma multiforme (GBM); wnt signalling; hedgehog-gLI1; rho/rhzo kinase (ROCK); beta-catenin; neoplasm; CANCER; STRATEGIES; MECHANISMS;
D O I：
10.2174/1573394716999201007125709
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly targeting aged populations. The average survival is only 15 months from the date of occurrence. It is often observed that, the invasive nature of the tumour is the main reason for poor prognosis and strong recurrence of GBM in patients even after prescribed treatments. Despite all types of therapies, it is necessary to understand the various molecular mechanisms and signalling pathways to identify targets for GBM treatment. This compilation is specifically designed to discuss Wnt signalling and Hedgehog-GLI1 pathways, which have positive and negative regulation against GBM. The recent research finding associated with different signalling pathways for GBM has also been discussed within this article.
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页码：89 / 92
页数：4
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