Glioblastoma Multiforme and its Cell Interruption

被引：2

作者：

Bhattacharya, Sankha ^{[1
]}

机构：

[1] ISF Coll Pharm, Dept Pharmaceut, GT Rd NH-95, Moga 142001, Punjab, India

来源：

CURRENT CANCER THERAPY REVIEWS | 2021年 / 17卷 / 02期

关键词：

Glioblastoma multiforme (GBM); wnt signalling; hedgehog-gLI1; rho/rhzo kinase (ROCK); beta-catenin; neoplasm; CANCER; STRATEGIES; MECHANISMS;

D O I：

10.2174/1573394716999201007125709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly targeting aged populations. The average survival is only 15 months from the date of occurrence. It is often observed that, the invasive nature of the tumour is the main reason for poor prognosis and strong recurrence of GBM in patients even after prescribed treatments. Despite all types of therapies, it is necessary to understand the various molecular mechanisms and signalling pathways to identify targets for GBM treatment. This compilation is specifically designed to discuss Wnt signalling and Hedgehog-GLI1 pathways, which have positive and negative regulation against GBM. The recent research finding associated with different signalling pathways for GBM has also been discussed within this article.

引用

页码：89 / 92

页数：4

共 26 条

[1] Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
Amaravadi, Ravi K.
Lippincott-Schwartz, Jennifer
Yin, Xiao-Ming
Weiss, William A.
Takebe, Naoko
Timmer, William
DiPaola, Robert S.
Lotze, Michael T.
White, Eileen
[J]. CLINICAL CANCER RESEARCH, 2011, 17 (04) : 654 - 666
[2] On glioblastoma and the search for a cure: where do we stand?
Bianco, John
Bastiancich, Chiara
Jankovski, Aleksander
des Rieux, Anne
Preat, Veronique
Danhier, Fabienne
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (13) : 2451 - 2466
[3] Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms
Bodduluru, Lakshmi Narendra
Kasala, Eshvendar Reddy
Thota, Nagaraju
Barua, Chandana C.
Sistla, Ramakrishna
[J]. TOXICOLOGY IN VITRO, 2014, 28 (05) : 1026 - 1035
[4] Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
Bourboulia, Dimitra
Stetler-Stevenson, William G.
[J]. SEMINARS IN CANCER BIOLOGY, 2010, 20 (03) : 161 - 168
[5] Who's afraid of Susan Sontag? or, the myths and metaphors of cancer reconsidered
Clow, B
[J]. SOCIAL HISTORY OF MEDICINE, 2001, 14 (02) : 293 - 312
[6] Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front
De Wever, Olivier
Pauwels, Patrick
De Craene, Bram
Sabbah, Michele
Emami, Shahin
Redeuilh, Gerard
Gespach, Christian
Bracke, Marc
Berx, Geert
[J]. HISTOCHEMISTRY AND CELL BIOLOGY, 2008, 130 (03) : 481 - 494
[7] Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients
Figueroa, Javier M.
Skog, Johan
Akers, Johnny
Li, Hongying
Komotar, Ricardo
Jensen, Randy
Ringel, Florian
Yang, Isaac
Kalkanis, Steven
Thompson, Reid
LoGuidice, Lori
Berghoff, Emily
Parsa, Andrew
Liau, Linda
Curry, William
Cahill, Daniel
Bettegowda, Chetan
Lang, Frederick F.
Chiocca, E. Antonio
Henson, John
Kim, Ryan
Breakefield, Xandra
Chen, Clark
Messer, Karen
Hochberg, Fred
Carter, Bob S.
[J]. NEURO-ONCOLOGY, 2017, 19 (11) : 1494 - 1502
[8] Mouse models of brain tumors and their applications in preclinical trials
Fomchenko, Elena I.
Holland, Eric C.
[J]. CLINICAL CANCER RESEARCH, 2006, 12 (18) : 5288 - 5297
[9] Tyrosine kinase targets in drug discovery
Grosios, K
Traxler, P
[J]. DRUGS OF THE FUTURE, 2003, 28 (07) : 679 - 697
[10] The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
He, Yang
Roos, Wynand P.
Wu, Qianchao
Hofmann, Thomas G.
Kaina, Bernd
[J]. MOLECULAR CANCER RESEARCH, 2019, 17 (05) : 1129 - 1141

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