Analysis and interpretation of results based on patient-reported outcomes

被引：46

作者：

Sloan, Jeff A. ^{[1
]}

Dueck, Amylou C. ^{[1
]}

Erickson, Pennifer A. ^{[2
,3
]}

Guess, Harry ^{[4
]}

Revicki, Dennis A. ^{[6
]}

Santanello, Nancy C. ^{[5
]}

Sloan, Jeff A. ^{[1
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, 200 1st St SW, Rochester, MN 55905 USA

[2] Penn State Univ, Hershey Med Sch, Dept Biobehav Hlth, State Coll, PA USA

[3] Penn State Univ, Hershey Med Sch, Dept Hlth Evaluat Sci, State Coll, PA USA

[4] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[5] Merck Res Labs, West Point, PA USA

[6] United BioSource Corp, Ctr Hlth Outcomes Res, Bethesda, MD USA

来源：

VALUE IN HEALTH | 2007年 / 10卷

关键词：

clinical significance; minimally important difference; missing data; patient-reported outcomes; statistical analysis;

D O I：

10.1111/j.1524-4733.2007.00273.x

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

This article is part of a series of manuscripts dealing with the incorporation of patient-reported outcomes (PROs) into clinical trials. The issues dealt with in this manuscript concern the common pitfalls to avoid in statistical analysis and interpretation of PROs. Specifically, the questions addressed by this manuscript involve the analysis pitfalls with PRO data in clinical trials and how can they be avoided (e.g.,missing data, multiplicity, null results etc.). The manuscript provides key literature for existing resources and proposes new guidelines.

引用

页码：S106 / S115

页数：10

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