Complicated and persistent severe COVID-19 pneumonia in a recipient of allogeneic haematopoietic stem cell transplant

被引：4

作者：

Lazzari, Lorenzo ^{[1
]}

Oltolini, Chiara ^{[2
]}

Ciceri, Fabio ^{[1
]}

Giglio, Fabio ^{[1
]}

机构：

[1] IRCCS Osped San Raffaele, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[2] IRCCS Osped San Raffaele, Dept Infect Dis, Milan, Italy

来源：

BMJ CASE REPORTS | 2021年 / 14卷 / 10期

关键词：

COVID-19; haematology (incl blood transfusion);

D O I：

10.1136/bcr-2021-245992

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the case of a 45-year-old man affected by T-cell acute lymphoblastic leukaemia and diagnosed with COVID-19 early after an allogeneic haematopoietic stem cell transplant. The infectious disease was characterised by a severe and prolonged course, further complicated by a spontaneous pneumomediastinum and pneumopericardium. We successfully treated this patient with the antiviral drug remdesivir associated with two courses of COVID-19 convalescent plasma. This case report represents a good example of the typical clinical course of COVID-19 in severely immunosuppressed patients and gives evidence that in this population only a prompt treatment directed towards viral clearance can face the absence of a valid immune reactivity.

引用

页数：4

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