High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma

被引：14

作者：

Wang, Juncheng ^{[1
,2
]}

Qin, Yuexiang ^{[1
,2
,3
]}

Zhu, Gangcai ^{[4
]}

Huang, Donghai ^{[1
,2
]}

Wei, Ming ^{[1
,2
]}

Li, Guo ^{[1
,2
]}

She, Li ^{[1
,2
]}

Zhang, Diekuo ^{[1
,2
]}

Wang, Gang ^{[1
,2
]}

Chen, Xiyu ^{[1
,2
]}

Shen, Zhe ^{[1
,2
]}

Qiu, Yuanzheng ^{[1
,2
]}

Wang, Yunyun ^{[1
,2
]}

Tan, Haolei ^{[5
]}

Tan, Pingqing ^{[5
]}

Chen, Jie ^{[5
]}

Zhang, Xin ^{[1
,2
]}

Liu, Yong ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Otolaryngol Major Dis Res Key Lab Hunan Prov, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, Dept Hlth Management, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Otolaryngol Head & Neck Surg, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China

[5] Cent South Univ, Hunan Canc Hosp, Affiliated Tumor Hosp, Dept Head & Neck Surg,Xiangya Med Sch, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 27期

基金：

中国国家自然科学基金;

关键词：

CCL18; LSCC; Prognosis; Tumor associated Macrophage; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; MECHANISMS; HEALTHY;

D O I：

10.7150/jca.37515

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. In addition, the correlations between serum CCL18 and clinicopathological parameters were analyzed. Our data revealed that serum CCL18 was obviously increased in patients with LSCC. Moreover, serum CCL18 level was significantly associated with primary tumor site (Glottic vs Others), T classification (T1+T2 vs T3+T4), clinical stage (I+II vs III+IV) and lymph node metastasis (N0 vs N+). Survival analysis demonstrated that patients with high serum CCL18 displayed a shorter survival time than those in patients with low serum CCL18. Importantly, serum CCL18 level and clinical stage were independent prognostic factors in patients with LSCC. Taken together, serum CCL18 could be used as a promising biomarker in patients with LSCC.

引用

页码：6910 / 6914

页数：5

共 50 条

[21] High microRNA-23a expression in laryngeal squamous cell carcinoma is associated with poor patient prognosis
Zhang, Xiao-Wen
Liu, Ning
Chen, Sheng
Wang, Ye
Zhang, Zhao-Xiong
Sun, Yuan-Yuan
Qiu, Guang-Bin
Fu, Wei-Neng
DIAGNOSTIC PATHOLOGY, 2015, 10
[22] High microRNA-23a expression in laryngeal squamous cell carcinoma is associated with poor patient prognosis
Xiao-Wen Zhang
Ning Liu
Sheng Chen
Ye Wang
Zhao-Xiong Zhang
Yuan-Yuan Sun
Guang-Bin Qiu
Wei-Neng Fu
Diagnostic Pathology, 10
[23] CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis
Qiao, Bing
Chen, Lei
Cheng, Qianwen
Wang, Guangqi
Li, Qun
Zhang, Bo
Li, Junying
Hu, Yu
Sun, Chunyan
CARCINOGENESIS, 2023, 44 (01) : 38 - 45
[24] High Expression of Tetraspanin CD63 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma
Matsumoto, Yasunori
Otsuka, Ryota
Nishioka, Yuri
Toyozumi, Takeshi
Sekino, Nobufumi
Shiraishi, Tadashi
Okada, Koichiro
Kamata, Toshiki
Iida, Shinichiro
Morishita, Hiroki
Makiyama, Tenshi
Yamada, Masanari
Matsubara, Hisahiro
ONCOLOGY, 2025,
[25] Serum cytokine profile of laryngeal squamous cell carcinoma patients
Sotirovic, J.
Peric, A.
Vojvodic, D.
Baletic, N.
Zaletel, I.
Stanojevic, I.
Erdoglija, M.
Milojevic, M.
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2017, 131 (05) : 455 - 461
[26] Notch I Overexpression Associates With Poor Prognosis in Human Laryngeal Squamous Cell Carcinoma
Li, Dawei
Dong, Pin
Wu, Chunping
Cao, Pengyu
Zhou, Liang
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2014, 123 (10) : 705 - 710
[27] High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Tang, Yuting
Ge, Shengdong
Zheng, Xiao
Zheng, Jiejiao
DIAGNOSTIC PATHOLOGY, 2022, 17 (01)
[28] Upregulation of METTL3 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma
Xia, Tian-Liang
Yan, Shu-Mei
Yuan, Li
Zeng, Mu-Sheng
CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 5729 - 5737
[29] Decreased Tumor Suppressor Candidate 3 Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma
Yu, Xinshuang
Zhang, Jiandong
Zhong, Hua
Liu, Fengjun
Liang, Ning
Wang, Yao
Meng, Xiangjiao
Du, Juan
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2016, 13 (12): : 963 - 969
[30] Overexpression of EIF5A2 Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma
Lin, Yueh-Min
Chen, Mei-Ling
Chen, Chia-Lo
Yeh, Chung-Min
Sung, Wen-Wei
DIAGNOSTICS, 2020, 10 (07)

← 1 2 3 4 5 →