High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma

被引：14

作者：

Wang, Juncheng ^{[1
,2
]}

Qin, Yuexiang ^{[1
,2
,3
]}

Zhu, Gangcai ^{[4
]}

Huang, Donghai ^{[1
,2
]}

Wei, Ming ^{[1
,2
]}

Li, Guo ^{[1
,2
]}

She, Li ^{[1
,2
]}

Zhang, Diekuo ^{[1
,2
]}

Wang, Gang ^{[1
,2
]}

Chen, Xiyu ^{[1
,2
]}

Shen, Zhe ^{[1
,2
]}

Qiu, Yuanzheng ^{[1
,2
]}

Wang, Yunyun ^{[1
,2
]}

Tan, Haolei ^{[5
]}

Tan, Pingqing ^{[5
]}

Chen, Jie ^{[5
]}

Zhang, Xin ^{[1
,2
]}

Liu, Yong ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Otolaryngol Major Dis Res Key Lab Hunan Prov, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, Dept Hlth Management, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Otolaryngol Head & Neck Surg, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China

[5] Cent South Univ, Hunan Canc Hosp, Affiliated Tumor Hosp, Dept Head & Neck Surg,Xiangya Med Sch, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 27期

基金：

中国国家自然科学基金;

关键词：

CCL18; LSCC; Prognosis; Tumor associated Macrophage; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; MECHANISMS; HEALTHY;

D O I：

10.7150/jca.37515

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. In addition, the correlations between serum CCL18 and clinicopathological parameters were analyzed. Our data revealed that serum CCL18 was obviously increased in patients with LSCC. Moreover, serum CCL18 level was significantly associated with primary tumor site (Glottic vs Others), T classification (T1+T2 vs T3+T4), clinical stage (I+II vs III+IV) and lymph node metastasis (N0 vs N+). Survival analysis demonstrated that patients with high serum CCL18 displayed a shorter survival time than those in patients with low serum CCL18. Importantly, serum CCL18 level and clinical stage were independent prognostic factors in patients with LSCC. Taken together, serum CCL18 could be used as a promising biomarker in patients with LSCC.

引用

页码：6910 / 6914

页数：5

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