Association between body fat parameters and arterial stiffness

被引:30
作者
Kim, Hack-Lyoung [1 ]
Ahn, Dong-Won [2 ]
Kim, Su Hwan [2 ]
Lee, Dong Seok [2 ]
Yoon, Soon Ho [3 ]
Zo, Joo-Hee [1 ]
Kim, Myung-A [1 ]
Jeong, Ji Bong [2 ]
机构
[1] Seoul Natl Univ, Boramae Med Ctr, Coll Med, Div Cardiol,Dept Internal Med, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Div Gastroenterol & Hepatol, Dept Internal Med,Boramae Med Ctr, 20 Borame Ro 5 Gil, Seoul 07061, South Korea
[3] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Radiol, Seoul, South Korea
关键词
PULSE-WAVE VELOCITY; INSULIN-RESISTANCE; ABDOMINAL OBESITY; AORTIC STIFFNESS; WEIGHT-LOSS; MASS INDEX; RISK; MORTALITY; DISEASE; HEALTH;
D O I
10.1038/s41598-021-00175-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The influence of body fat on arterial stiffness remains controversial. This study was performed to investigate the associations between four different types of body fat parameters and brachial-ankle pulse wave velocity (baPWV). A total of 3758 subjects (mean age, 53.4 +/- 8.8 years; females, 36.3%) who underwent health check-up were retrospectively analyzed. Anthropometric parameters including body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR) were assessed, and visceral fat area (VFA) was calculated by bioelectrical impedance analysis. In simple linear correlation analyses, baPWV was associated with WC, WHR and VFA (P < 0.001 for each), but not with BMI (P = 0.175). In multivariable analyses, BMI and WC were not associated with baPWV (P > 0.05 for each). Even after controlling for potential confounders, higher baPWV was significantly associated not only with higher WHR [for > 0.90 in men and > 0.85 in women: odds ratio (OR), 1.23; 95% confidence interval (CI), 1.06-1.42; P = 0.005; for the highest tertile compared to the lowest tertile: OR, 1.38; 95% CI, 1.15-1.66; P < 0.001], but also with higher VFA (for >= 100 cm(2): OR, 1.39; 95% CI, 1.20-1.60; P < 0.001; for the highest tertile compared to the lowest tertile: OR, 1.77; 95% CI, 1.48-2.12; P < 0.001). Our study showed that baPWV was correlated with WHR and VFA, but not with BMI and WC. This implies that arterial stiffness may be more strongly associated with abdominal obesity than overall obesity.
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页数:8
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