Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently required. MicroRNAs represent promising targets for such new therapies, as they are involved in the pathology of multiple types of cancer, and aberrant expression of several miRNAs has already been shown in osteosarcoma. In this study, we identified silencing of miR-127-3p and miR-376a-3p in osteosarcoma cell lines and tissues and investigated their role as potential tumor suppressors in vitro and in vivo. Transfection of osteosarcoma cells (n = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. In contrast, we could not detect any influence of miRNA restoration on cell cycle and apoptosis induction. The effects of candidate miRNA restoration on tumor engraftment and growth in vivo were analyzed using a chicken chorioallantoic membrane (CAM) assay. Cells transfected with mir-127-3p and miR-376a-3p showed reduced tumor take rates and tumor volumes and a significant decrease of the cumulative tumor volumes to 41% and 54% compared to wildtype cells. The observed tumor suppressor function of both analyzed miRNAs indicates these miRNAs as potentially valuable targets for the development of new therapeutic strategies for the treatment of osteosarcoma.
机构:
Lambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, IndonesiaLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Huldani, Huldani
Alshahrani, Shadia Hamoud
论文数: 0引用数: 0
h-index: 0
机构:
King Khalid Univ, Med Surg Nursing Dept, Khamis Mushate, Saudi ArabiaLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Alshahrani, Shadia Hamoud
Almajidi, Yasir Qasim
论文数: 0引用数: 0
h-index: 0
机构:
Baghdad Coll Med Sci, Dept Pharm Pharmaceut, Baghdad, IraqLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Almajidi, Yasir Qasim
Romero-Parra, Rosario Mireya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Continental, Lima, PeruLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Romero-Parra, Rosario Mireya
论文数: 引用数:
h-index:
机构:
Hjazi, Ahmed
Alsaab, Hashem O.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Dept Pharmaceut & Pharmaceut Technol, Taif 21944, Saudi ArabiaLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Alsaab, Hashem O.
Oudaha, Khulood H.
论文数: 0引用数: 0
h-index: 0
机构:
Al Ayen Univ, Coll Pharm, Pharmaceut Chem Dept, Thi Qar, IraqLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Oudaha, Khulood H.
Hussien, Beneen M.
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, IraqLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Hussien, Beneen M.
Ahmed, Muhja
论文数: 0引用数: 0
h-index: 0
机构:
Al Farahidi Univ, Med Tech Coll, Baghdad, IraqLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
Ahmed, Muhja
Fard, Seyed Reza Hosseini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Biochem Dept, Tehran, Iran
Univ Tehran Med Sci, Sch Med, Dept Clin Biochem, Tehran, IranLambung Mangkurat Univ, Fac Med, Dept Physiol, Banjarmasin, South Kalimanta, Indonesia
机构:
Heze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Qiao, Baohua
Wang, Qingzhi
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Wang, Qingzhi
Zhao, Yuying
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
Zhao, Yuying
Wu, Jingli
论文数: 0引用数: 0
h-index: 0
机构:
Heze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R ChinaHeze Municipal Hosp, 28888 Caozhou Rd, Heze 274000, Shandong, Peoples R China
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Maximov, Vadim V.
Akkawi, Rania
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Akkawi, Rania
Khawaled, Saleh
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Khawaled, Saleh
Salah, Zaidoun
论文数: 0引用数: 0
h-index: 0
机构:
Al Quds Univ, Al Quds Bard Coll, Al Bireh, East Jerusalem, PalestineHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Salah, Zaidoun
Jaber, Lina
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Jaber, Lina
Barhoum, Ahlam
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Barhoum, Ahlam
Or, Omer
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Dept Orthoped Surg, Hadassah Med Ctr, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Or, Omer
论文数: 引用数:
h-index:
机构:
Galasso, Marco
Kurek, Kyle C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calgary, Alberta Childrens Hosp & Res Inst, Dept Pathol, Calgary, AB, Canada
Univ Calgary, Alberta Childrens Hosp & Res Inst, Med Genet Cumming Sch Med, Calgary, AB, CanadaHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Kurek, Kyle C.
Yavin, Eylon
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, Jerusalem, IsraelHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Yavin, Eylon
Aqeilan, Rami, I
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
Ohio State Univ, Wexner Med Ctr, Dept Canc Biol & Genet, Columbus, OH 43210 USAHebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Dept Immunol & Canc Res IMRIC, Hadassah Med Sch Ein Kerem, Jerusalem, Israel
机构:
Second Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China
Xu, Guoxing
Wang, Jin
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China
Wang, Jin
Jia, Yixin
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China
Jia, Yixin
Shen, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China
Shen, Feng
Han, Wensheng
论文数: 0引用数: 0
h-index: 0
机构:
Binzhou Medial Univ, Yantai Affiliated Hosp, Dept Orthoped, Yantai, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China
Han, Wensheng
Kang, Yifan
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Orthoped, Changhai Hosp, Shanghai 200433, Peoples R China