Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells

被引：71

作者：

Rosen, O

Thiel, A

Massenkeil, G

Hiepe, F

Häupl, T

Radtke, H

Burmester, GR

Gromnica-Ihle, E

Radbruch, A

Arnold, R

机构：

[1] Univ Hosp Charite, Dept Hematol Oncol, D-10117 Berlin, Germany

[2] Univ Hosp Charite, Dept Rheumatol, D-10117 Berlin, Germany

[3] Univ Hosp Charite, Dept Transfus Med, D-10117 Berlin, Germany

[4] German Canc Res Ctr Rheumatol, Berlin, Germany

[5] Rheumaklin Berlin Buch, Berlin, Germany

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 04期

关键词：

autologous stem-cell transplantation; polychondritis; refractory autoimmune disease; systemic lupus erythematosus; systemic sclerosis;

D O I：

10.1186/ar107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.

引用

页码：327 / 336

页数：10

共 22 条

[1] Immunoablative high-dose cyclophosphamide without stem-cell rescue for refractory, severe autoimmune disease [J].