Universal Rink-isonitrile resin:: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines

被引：67

作者：

Chen, JJ ^{[1
]}

Golebiowski, A ^{[1
]}

McClenaghan, J ^{[1
]}

Klopfenstein, SR ^{[1
]}

West, L ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Combinatorial Chem Grp, Mason, OH 45040 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 12期

关键词：

combinatorial synthesis; solid-phase synthesis; heterocyclic chemistry; multi-component reaction;

D O I：

10.1016/S0040-4039(01)00159-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rink resin was converted to isonitrile resin after formylation with HCO2H/diisopropylcarbodiimide followed by POCl3/diisopropylethylamine dehydration. This polymer-supported isonitrile was then employed in the multi-component synthesis of imidazo[1,2-a]pyridines. The resin-bound imidazo[1,2-a]pyridine was acylated and spontaneously released by acyl chloride treatment in dichloroethane. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2269 / 2271

页数：3

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