LncRNA UCA1 in anti-cancer drug resistance

被引：134
|
作者：
Wang, Haohao [1 ,2 ]
Guan, Zhonghai [1 ]
He, Kuifeng [1 ,2 ]
Qian, Jiong [1 ]
Cao, Jiang [3 ]
Teng, Lisong [1 ,2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Ctr Canc, Hangzhou, Zhejiang, Peoples R China
[2] Key Lab Precis Diag & Treatment Hepatobiliary & P, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Coll Med, Clin Res Ctr, Hangzhou, Zhejiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 38期
基金：
中国国家自然科学基金;
关键词：
long non-coding RNA; UCA1; chemoresistance; cancer; LONG NONCODING RNA; CARCINOMA-ASSOCIATED; CHRONIC MYELOID-LEUKEMIA; CELL LUNG-CANCER; ENHANCES TAMOXIFEN RESISTANCE; TYROSINE KINASE INHIBITORS; BREAST-CANCER; MULTIDRUG-RESISTANCE; POOR-PROGNOSIS; MOLECULAR-MECHANISMS;
D O I：
10.18632/oncotarget.18344
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The pivotal role of the long non-coding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) in anti-cancer drug resistance has been confirmed in many cancers. Overexpression of lncRNA UCA1 correlates with resistance to chemotherapeutics such as cisplatin, gemcitabine, 5-FU, tamoxifen, imatinib and EGFR-TKIs, whereas lncRNA UCA1 knockdown restores drug sensitivity. These studies highlight the potential of lncRNA UCA1 as a diagnostic and prognostic biomarker, and a therapeutic target in malignant tumors. In this review, we address the role of lncRNA UCA1 in anti-cancer drug resistance and discuss its potential in future clinical applications.
引用
收藏
页码：64638 / 64650
页数：13
相关论文
共 50 条
  • [1] LncRNA UCA1 as a potential therapeutic target for drug resistance in colorectal cancer
    Doxtater, Kyle D.
    Tripathi, Manish K.
    CANCER RESEARCH, 2023, 83 (07)
  • [2] Crosstalk between the lncRNA UCA1 and microRNAs in cancer
    Xuan, Wei
    Yu, Hongyu
    Zhang, Xiaoling
    Song, Dandan
    FEBS LETTERS, 2019, 593 (15) : 1901 - 1914
  • [3] UCA1 lncRNA in metastases and prognosis
    Song, Wei
    Wang, Kai
    Zou, Shu-Bing
    PANMINERVA MEDICA, 2017, 59 (03) : 278 - 279
  • [4] The prognostic value and mechanisms of lncRNA UCA1 in human cancer
    Yao, Fei
    Wang, Qiang
    Wu, Qingming
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 7685 - 7696
  • [5] Silence of lncRNA UCA1 rescues drug resistance of cisplatin to non-small-cell lung cancer cells
    Liu, Xiaojing
    Huang, Zhisheng
    Qian, Wei
    Zhang, Qing
    Sun, Jian
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (06) : 9243 - 9249
  • [6] Expression of lncRNA UCA1 in ovarian cancer and its clinical significance
    Qiu, Y. R.
    Zhao, M. Y.
    Sun, L.
    Yang, B. C.
    Hei, K. W.
    Du, X.
    Li, Y. M.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2017, 38 (02) : 191 - 195
  • [7] Unraveling UCA1 lncRNA prognostic utility in urothelial bladder cancer
    Avgeris, Margaritis
    Tsilimantou, Anastasia
    Levis, Panagiotis K.
    Rampias, Theodoros
    Papadimitriou, Maria-Alexandra
    Panoutsopoulou, Konstantina
    Stravodimos, Konstantinos
    Scorilas, Andreas
    CARCINOGENESIS, 2019, 40 (08) : 965 - 974
  • [8] LncRNA UCA1 modulates glucose metabolism proteins in colorectal cancer
    Leslie, Sophia
    Doxtater, Kyle
    Lopez, Samantha
    Anilkumar, Adithya
    Jaggi, Meena
    Chauhan, Subhash
    Tripathi, Manish
    CANCER RESEARCH, 2022, 82 (12)
  • [9] Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma
    Fu, Jiali
    Pan, Jingjing
    Yang, Xiang
    Zhang, Yan
    Shao, Fanggui
    Chen, Jie
    Huang, Kate
    Wang, Yumin
    CANCER CELL INTERNATIONAL, 2021, 21 (01)
  • [10] Tissue expression level of lncRNA UCA1 is a prognostic biomarker for colorectal cancer
    Jiang, Hong
    Chen, Ying-Tao
    Fu, Xue-Guang
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (04): : 4241 - 4246
12345