Ursodeoxycholic acid in eradication of Helicobacter pylori

In this pilot study we investigated the value of a fourteen-day regimen with amoxicillin (1 g bid), ranitidine (300 mg/d) and ursodeoxycholic acid 1300 mg tid) in eradicating Helicobacter pylori. 15 patients with non-ulcer dyspepsia (reactive CLO(R) test, positive histology or C-13 urea breath test) were enrolled, Helicobacter pylori was eradicated in 6 of 13 patients (C-13 urea breath test 4 weeks after the end of treatment). 2 patients were not followed up because of too short treatment (<1 week), Only 5/15 patients had no side effects (33%), These results strongly suggest that ursodeoxycholic acid in this application regimen is not of use in eradicating Helicobacter pylori.