Association between EGF+61A/G polymorphism and gastric cancer in Caucasians

被引:19
作者
Araujo, Ana Paula [1 ]
Costa, Bruno M. [2 ]
Pinto-Correia, Ana L. [1 ]
Fragoso, Maria [3 ]
Ferreira, Paula [1 ]
Dinis-Ribeiro, Mario [4 ,5 ]
Costa, Sandra [2 ]
Reis, Rui M. [2 ]
Medeiros, Rui [1 ,6 ,7 ]
机构
[1] Portuguese Inst Oncol Porto, Mol Oncol Grp, P-4200072 Oporto, Portugal
[2] Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, P-4704553 Braga, Portugal
[3] Portuguese Inst Oncol Porto, Dept Oncol, P-4200072 Oporto, Portugal
[4] Portuguese Inst Oncol Porto, Dept Gastroenterol, P-4200072 Oporto, Portugal
[5] Univ Porto, Cintesisi Fac Med, P-4200072 Oporto, Portugal
[6] Fernando Pessoa Univ, Fac Hlth Sci, Ctr Estudos Biomed, P-4200150 Oporto, Portugal
[7] Abel Salazar Inst Biomed Sci, P-4099003 Oporto, Portugal
关键词
Epidermal growth factor polymorphism; Epidermal growth factor receptor; Gastric cancer; EPIDERMAL-GROWTH-FACTOR; EGF GENE; MALIGNANT-MELANOMA; GRANULOSA-CELLS; ERBB RECEPTORS; RISK; OVARIAN; SUSCEPTIBILITY; POPULATION; EXPRESSION;
D O I
10.3748/wjg.v17.i4.488
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to geno-type EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. (C) 2011 Baishideng. All rights reserved.
引用
收藏
页码:488 / 492
页数:5
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