Flash NanoPrecipitation of organic actives and block copolymers using a confined impinging jets mixer

被引：349

作者：

Johnson, BK ^{[1
]}

Prud'homme, RK ^{[1
]}

机构：

[1] Princeton Univ, Princeton, NJ USA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2003年 / 56卷 / 10期

关键词：

D O I：

10.1071/CH03115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new technology to form nanoparticles of hydrophobic organic actives at high concentration and yield, as well as methods to characterize the process, are presented. In Flash NanoPrecipitation, an organic active and an amphiphilic diblock copolymer are molecularly dissolved in an organic phase and mixed rapidly with a miscible anti-solvent to afford precipitation of the active with a tunable, narrow submicron particle size distribution from 1 mum to 80 nm. The enabling components are a novel 'analytical' ( quantified mixing time) confined impinging jets (CIJ) mixer for millisecond stream homogenization and amphiphilic diblock copolymers which alter the organic nucleation and growth, provide steric stabilization for the particles, and offer a functional surface for the particle. Applications in enhanced pharmaceutical delivery, dye preparation, and pesticide formulation are specifically targeted.

引用

页码：1021 / 1024

页数：4