Synthesis and Biological Evaluation of (N-(3-methoxyphenyl)-4-((aryl-1H-1,2,3-triazol-4-yl)methyl) thiomorpholine-2-carboxamide 1,1-Dioxide Hybrids as Antiproliferative Agents

被引：10
|
作者：
Battula, Kumara Swamy [1 ]
Narsimha, Sirassu [1 ]
Thatipamula, Ranjith Kumar [1 ]
Reddy, Yellu Narsimha [2 ]
Nagavelli, Vasudeva Reddy [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Telangana, India
[2] Kakatiya Univ, Dept Pharmacol & Toxicol, Warangal 506009, Telangana, India
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 29期
关键词：
1; 2; 3-triazole; cycloaddition; thiomorpholine; in vitro antiproliferative activity; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; DERIVATIVES; ANTICANCER; ANTIOXIDANT; CANCER; ANTIMYCOBACTERIAL; INHIBITORS; ANALOGS; POTENT;
D O I：
10.1002/slct.201701902
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new thirteen N-(3-Methoxyphenyl)thiomorpholine-2-carboxamide 1, 1-dioxide derived 1, 4-disubtituted 1, 2, 3-triazole hybrids (7a-7m) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by (HNMR)-H-1, (CNMR)-C-13, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to invitro anticancer activity against three human cancer cell lines MCF-7, Hela and A-549 and 2-hydroxy phenyl, 2-methoxy phenyl and 3-methoxy phenyl substituted (7f, 7g and 7h) derivatives were found to possess potential antiproliferative activity.
引用
收藏
页码：9595 / 9598
页数：4
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