Synthesis and Biological Evaluation of (N-(3-methoxyphenyl)-4-((aryl-1H-1,2,3-triazol-4-yl)methyl) thiomorpholine-2-carboxamide 1,1-Dioxide Hybrids as Antiproliferative Agents

被引：10

作者：

Battula, Kumara Swamy ^{[1
]}

Narsimha, Sirassu ^{[1
]}

Thatipamula, Ranjith Kumar ^{[1
]}

Reddy, Yellu Narsimha ^{[2
]}

Nagavelli, Vasudeva Reddy ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Telangana, India

[2] Kakatiya Univ, Dept Pharmacol & Toxicol, Warangal 506009, Telangana, India

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 29期

关键词：

1; 2; 3-triazole; cycloaddition; thiomorpholine; in vitro antiproliferative activity; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; DERIVATIVES; ANTICANCER; ANTIOXIDANT; CANCER; ANTIMYCOBACTERIAL; INHIBITORS; ANALOGS; POTENT;

D O I：

10.1002/slct.201701902

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new thirteen N-(3-Methoxyphenyl)thiomorpholine-2-carboxamide 1, 1-dioxide derived 1, 4-disubtituted 1, 2, 3-triazole hybrids (7a-7m) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by (HNMR)-H-1, (CNMR)-C-13, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to invitro anticancer activity against three human cancer cell lines MCF-7, Hela and A-549 and 2-hydroxy phenyl, 2-methoxy phenyl and 3-methoxy phenyl substituted (7f, 7g and 7h) derivatives were found to possess potential antiproliferative activity.

引用

页码：9595 / 9598

页数：4

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