Morphological Analysis of Spherical Adsorptive Carbon Granules Using Three-Dimensional X-Ray Micro-computed Tomography

被引：1

作者：

Lzutsu, Ken-ichi ^{[1
]}

Abe, Yasuhiro ^{[1
]}

Yomota, Chikako ^{[2
]}

Yoshid, Hiroyuki ^{[1
]}

机构：

[1] Natl Inst Hlth Sci, Div Drugs, Kawasaki Ward, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan

[2] Kobe Pharmaceut Univ, Higashinada Ku, 4-19-1 Motoyamakitamachi, Kobe, Hyogo 6588558, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2020年 / 68卷 / 02期

关键词：

X-ray micro-computed tomography; spherical carbon granule; morphology; formulation; MICROTOMOGRAPHY; DISSOLUTION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The purpose of this study was to clarify applicability of three-dimensional X-ray micro-computed tomography (3D X-ray micro-CT) to elucidate interior morphology of spherical adsorptive carbon fine granules. Scanning of small single spherical granule hold on the rotating sample stage provided the structural information without particular preparation (e.g., slicing) that can affect the definite morphology. The three model formulations with similar appearance showed different internal structure in the 3D images, including large hollow in one of them. Other formulations showed some small empty or higher density area in the filled granules, suggesting uneven distribution of carbon. The results indicated relevance of the X-ray micro-CT analysis on the physical characterization of the spherical adsorptive carbon granule formulations.

引用

页码：179 / 180

页数：2

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