Are endogenous cardenolides controlled by atrial natriuretic peptide

被引：4

作者：

Brar, Kanwarjeet S. ^{[1
]}

Gao, Yonglin ^{[1
]}

El-Mallakh, Rif S. ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Res Program, 401 East Chestnut St,Suite 610, Louisville, KY 40202 USA

来源：

MEDICAL HYPOTHESES | 2016年 / 92卷

关键词：

Atrial natriuretic factor; Endogenous cardenolides; Ouabain; Ouabain-like factor; Digoxin; Digoxin-like factor; Natriuretic peptides; BOVINE ADRENOCORTICAL-CELLS; OUABAIN-LIKE FACTOR; NA-K-ATPASE; DIGITALIS-LIKE COMPOUNDS; LEFT-VENTRICULAR DYSFUNCTION; CONGESTIVE-HEART-FAILURE; SODIUM-PUMP INHIBITORS; IMMUNOREACTIVE FACTOR; HUMAN PLASMA; MYOCARDIAL-INFARCTION;

D O I：

10.1016/j.mehy.2016.04.030

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Endogenous cardenolides are digoxin-like substances and ouabain-like substances that have been implicated in the pathogenesis of hypertension and mood disorders in clinical and pre-clinical studies. Regulatory signals for endogenous cardenolides are still unknown. These endogenous compounds are believed to be produced by the adrenal gland in the periphery and the hypothalamus in the central nervous system, and constitute part of an hormonal axis that may regulate the catalytic activity of the a subunit of Na+/K+-ATPase. A review of literature suggests that there is great overlap in physiological environments that are associated with either elevations or reductions in the levels of atrial natriuretic peptide (ANP) and endogenous cardenolides. This suggests that these two factors may share a common regulatory signal or perhaps that ANP may be involved in the regulation of endogenous cardenolides. (C) 2016 Published by Elsevier Ltd.

引用

页码：21 / 25

页数：5

共 88 条

[1] HIGH-AFFINITY OUABAIN BINDING-SITE AND LOW-DOSE POSITIVE INOTROPIC EFFECT IN RAT MYOCARDIUM [J].