Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

被引：423

作者：

Hawner, Christine ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 39期

关键词：

ARYL ALUMINUM REAGENTS; STEREOGENIC CENTERS; ENANTIOSELECTIVE SYNTHESIS; TRISUBSTITUTED ENONES; GRIGNARD-REAGENTS; ALKENYLBORONIC ACIDS; VIBSANIN-E; CONSTRUCTION; LIGANDS; 1,4-ADDITION;

D O I：

10.1039/c0cc02309d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.

引用

页码：7295 / 7306

页数：12

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