Primary structure of the pig homologue of human IHRP: Inter-alpha-trypsin inhibitor family heavy chain-related protein

被引：0
作者：
Hashimoto, K
Tobe, T
Sumiya, J
Sano, Y
ChoiMiura, NH
Ozawa, A
Yasue, H
Tomita, M
机构：
[1] SHOWA UNIV, SCH PHARMACEUT SCI, DEPT PHYSIOL CHEM, SHINAGAWA KU, TOKYO 142, JAPAN
[2] MINIST AGR FORESTRY & FISHERIES, NATL INST ANIM IND, ANIM GENOME RES GRP, TSUKUBA, IBARAKI 305, JAPAN
来源：
JOURNAL OF BIOCHEMISTRY | 1996年 / 119卷 / 03期
关键词：
acute phase protein; ITI heavy chain; pig IHRP; primary structure;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pig counterpart of human IHRP has been isolated from pig serum, and cDNA clones encoding this counterpart were isolated and characterized. The amino acid sequence of pig IHRP predicted from the nucleotide sequence of its cDNA shows reasonable homology to that of human IHRP. The nucleotide sequence of pig IHRP cDNA is identical to that of the mRNA partially determined to be the heavy chain of pig ITI [Buchman et al. (1990) Surgery 108, 560-566]; it is one of the major mRNAs induced in pig liver on cardiogenic shock. Thus we concluded that the reported mRNA should code for IHRP and not for the heavy chain of ITI. The pig IHRP also seems to be identical to pig-MAP, which was recently reported to be a major acute phase serum protein in pig [Gonzalez-Roman et al. (1995) FEBS Lett. 371, 227-230]. The results suggest that IHRP might be involved in acute phase reactions.
引用
收藏
页码：577 / 584
页数：8
相关论文
共 25 条
[11]   COMPLEMENTARY-DNA AND DERIVED AMINO-ACID SEQUENCE OF THE PRECURSOR OF ONE OF THE 3 PROTEIN-COMPONENTS OF THE INTER-ALPHA-TRYPSIN INHIBITOR COMPLEX [J].
GEBHARD, W ;
SCHREITMULLER, T ;
HOCHSTRASSER, K ;
WACHTER, E .
FEBS LETTERS, 1988, 229 (01) :63-67
[12]  
GONZALEZRAMON N, 1995, FEBS LETT, V371, P227, DOI 10.1016/0014-5793(95)00882-A
[13]   CARBOHYDRATE AS COVALENT CROSSLINK IN HUMAN INTER-ALPHA-TRYPSIN INHIBITOR - A NOVEL PLASMA-PROTEIN STRUCTURE [J].
JESSEN, TE ;
FAARVANG, KL ;
PLOUG, M .
FEBS LETTERS, 1988, 230 (1-2) :195-200
[14]   AN ANALYSIS OF 5'-NONCODING SEQUENCES FROM 699 VERTEBRATE MESSENGER-RNAS [J].
KOZAK, M .
NUCLEIC ACIDS RESEARCH, 1987, 15 (20) :8125-8148
[15]   POINT MUTATIONS DEFINE A SEQUENCE FLANKING THE AUG INITIATOR CODON THAT MODULATES TRANSLATION BY EUKARYOTIC RIBOSOMES [J].
KOZAK, M .
CELL, 1986, 44 (02) :283-292
[16]   CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].
LAEMMLI, UK .
NATURE, 1970, 227 (5259) :680-+
[17]  
Maniatis T., 1989, MOL CLONING
[18]   CHONDROITIN SULFATE COVALENTLY CROSS-LINKS THE 3 POLYPEPTIDE-CHAINS OF INTER-ALPHA-TRYPSIN INHIBITOR [J].
MORELLE, W ;
CAPON, C ;
BALDUYCK, M ;
SAUTIERE, P ;
KOUACH, M ;
MICHALSKI, C ;
FOURNET, B ;
MIZON, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 221 (02) :881-888
[19]  
NISHIMURA H, 1995, FEBS LETT, V357, P207
[20]   THE SECONDARY STRUCTURE OF THE VON-WILLEBRAND-FACTOR TYPE-A DOMAIN IN FACTOR-B OF HUMAN-COMPLEMENT BY FOURIER-TRANSFORM INFRARED-SPECTROSCOPY - ITS OCCURRENCE IN COLLAGEN TYPE-VI, TYPE-VII, TYPE-XII AND TYPE-XIV, THE INTEGRINS AND OTHER PROTEINS BY AVERAGED STRUCTURE PREDICTIONS [J].
PERKINS, SJ ;
SMITH, KF ;
WILLIAMS, SC ;
HARIS, PI ;
CHAPMAN, D ;
SIM, RB .
JOURNAL OF MOLECULAR BIOLOGY, 1994, 238 (01) :104-119
123