cdc2 links the Drosophila cell cycle and asymmetric division machineries

被引：84

作者：

Tio, M ^{[1
]}

Udolph, G ^{[1
]}

Yang, XH ^{[1
]}

Chia, W ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

NATURE | 2001年 / 409卷 / 6823期

关键词：

D O I：

10.1038/35059124

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asymmetric cell divisions can be mediated by the preferential segregation of cell-fate determinants into one of two sibling daughters. In Drosophila neural progenitors, Inscuteable(1-3), Partner of Inscuteable(4,5) and Bazooka(6,7) localize as an apical cortical complex at interphase, which directs the apical-basal orientation of the mitotic spindle as well as the basal/cortical localization of the cell-fate determinants Numb(8,9) and/or Prospero(10,11) during mitosis. Although localization of these proteins shows dependence on the cell cycle, the involvement of cell-cycle components in asymmetric divisions has not been demonstrated. Here we show that neural progenitor asymmetric divisions require the cell-cycle regulator cdc2. By attenuating Drosophila cdc2 function without blocking mitosis, normally asymmetric progenitor divisions become defective, failing to correctly localize asymmetric components during mitosis and/or to resolve distinct sibling fates, cdc2 is not necessary for initiating apical complex formation during interphase; however, maintaining the asymmetric localization of the apical components during mitosis requires Cdc2/B-type cyclin complexes. Our findings link cdc2 with asymmetric divisions, and explain why the asymmetric localization of molecules like Inscuteable show cell-cycle dependence.

引用

页码：1063 / 1067

页数：6

共 30 条

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