Neuronal differentiation distinguishes supratentorial and infratentorial childhood ependymomas

被引:33
作者
Andreiuolo, Felipe [1 ]
Puget, Stephanie [1 ,2 ]
Peyre, Matthieu [1 ]
Dantas-Barbosa, Carmela [1 ]
Boddaert, Nathalie [3 ]
Philippe, Cathy [1 ]
Mauguen, Audrey [4 ]
Grill, Jacques [1 ,5 ]
Varlet, Pascale [6 ,7 ]
机构
[1] Univ Paris 11, INSERM UMR Vectorol & Anticanc Therapies 8203, Inst Gustave Roussy, F-94805 Villejuif, France
[2] Univ Paris 05, Hop Necker Enfants Malad, Dept Neurosurg, Paris, France
[3] Hop Necker Enfants Malad, Dept Radiol, Paris, France
[4] Inst Gustave Roussy, Dept Biostat & Epidemiol, Villejuif, France
[5] Inst Gustave Roussy, Dept Pediat & Adolescent Oncol, Villejuif, France
[6] Hop St Anne, Dept Neuropathol, F-75674 Paris, France
[7] Univ Paris 05, Inserm UMR U894, Paris, France
关键词
child; ependymoma; location; neurofilament; supratentorial; INTRACRANIAL EPENDYMOMAS; PROGNOSTIC-FACTORS; RADIAL GLIA; STEM-CELLS; TUMORS; SIGNATURES;
D O I
10.1093/neuonc/noq074
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ependymomas are glial neoplasms occurring in any location throughout the central nervous system and supposedly are derived from radial glia cells. Recent data suggest that these tumors may have different biological and clinical behaviors according to their location. Pediatric supratentorial and infratentorial ependymoma (SE and IE) were compared with respect to clinical and radiological parameters and immunohistochemistry (IHC). Neuronal markers were specifically assessed by IHC and quantitative PCR (qPCR). No single morphological or radiological characteristic was associated with location or any neuronal marker. However, there was a significant overexpression of neuronal markers in SE compared with IE: neurofilament light polypeptide 70 (NEFL)-positive tumor cells were found in 23 of 34 SE and in only 4 of 32 IE (P<.001). Among SE, 10 of 34 exhibited high expression of NEFL, defined as more than 5% positive cells. qPCR confirmed the upregulation of neuronal markers (NEFL, LHX2, FOXG1, TLX1, and NPTXR) in SE compared with IE. In addition, strong NEFL expression in SE was correlated with better progression-free survival (P=.007). Our results support the distinction of SE and IE. SEs are characterized by neuronal differentiation, which seems to be associated with better prognosis.
引用
收藏
页码:1126 / 1134
页数:9
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