mTOR signaling in cellular and organismal energetics

被引：233

作者：

Albert, Verena ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2015年 / 33卷

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

NOVO PYRIMIDINE SYNTHESIS; SKELETAL-MUSCLE; COMPLEX; MAMMALIAN TARGET; LIPID-METABOLISM; GROWTH-CONTROL; TRANSLATION INITIATION; GLUCOSE-HOMEOSTASIS; APPETITE REGULATION; PROTEIN-SYNTHESIS;

D O I：

10.1016/j.ceb.2014.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.

引用

收藏

页码：55 / 66

页数：12

相关论文

共 91 条

[1] Role of neuropeptides in appetite regulation and obesity - A review [J].

Arora, Sarika ;

Anubhuti .

NEUROPEPTIDES, 2006, 40 (06) :375-401

[2] Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 [J].

Ben-Sahra, Issam ;

Howell, Jessica J. ;

Asara, John M. ;

Manning, Brendan D. .

SCIENCE, 2013, 339 (6125) :1323-1328

[3] Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy [J].

Bentzinger, C. Florian ;

Romanino, Klaas ;

Cloetta, Dimitri ;

Lin, Shuo ;

Mascarenhas, Joseph B. ;

Oliveri, Filippo ;

Xia, Jinyu ;

Casanova, Emilio ;

Costa, Celine F. ;

Brink, Marijke ;

Zorzato, Francesco ;

Hall, Michael N. ;

Rueegg, Markus A. .

CELL METABOLISM, 2008, 8 (05) :411-424

[4] Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [J].

Bentzinger, C. Florian ;

Lin, Shuo ;

Romanino, Klaas ;

Castets, Perrine ;

Guridi, Maitea ;

Summermatter, Serge ;

Handschin, Christoph ;

Tintignac, Lionel A. ;

Hall, Michael N. ;

Rueegg, Markus A. .

SKELETAL MUSCLE, 2013, 3

[5] Where is mTOR and what is it doing there? [J].

Betz, Charles ;

Hall, Michael N. .

JOURNAL OF CELL BIOLOGY, 2013, 203 (04) :563-574

[6] mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology [J].

Betz, Charles ;

Stracka, Daniele ;

Prescianotto-Baschong, Cristina ;

Frieden, Maud ;

Demaurex, Nicolas ;

Hall, Michael N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (31) :12526-12534

[7] FGF21 regulates metabolism and circadian behavior by acting on the nervous system [J].

Bookout, Angie L. ;

de Groot, Marleen H. M. ;

Owen, Bryn M. ;

Lee, Syann ;

Gautron, Laurent ;

Lawrence, Heather L. ;

Ding, Xunshan ;

Elmquist, Joel K. ;

Takahashi, Joseph S. ;

Mangelsdorf, David J. ;

Kliewer, Steven A. .

NATURE MEDICINE, 2013, 19 (09) :1147-1152

[8] Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy [J].

Castets, Perrine ;

Lin, Shuo ;

Rion, Nathalie ;

Di Fulvio, Sabrina ;

Romanino, Klaas ;

Guridi, Maitea ;

Frank, Stephan ;

Tintignac, Lionel A. ;

Sinnreich, Michael ;

Rueegg, Markus A. .

CELL METABOLISM, 2013, 17 (05) :731-744

[9] Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program [J].

Chauvin, C. ;

Koka, V. ;

Nouschi, A. ;

Mieulet, V. ;

Hoareau-Aveilla, C. ;

Dreazen, A. ;

Cagnard, N. ;

Carpentier, W. ;

Kiss, T. ;

Meyuhas, O. ;

Pende, M. .

ONCOGENE, 2014, 33 (04) :474-483

[10] Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply [J].

Choo, Andrew Y. ;

Kim, Sang Gyun ;

Heiden, Matthew G. Vander ;

Mahoney, Sarah J. ;

Vu, Hieu ;

Yoon, Sang-Oh ;

Cantley, Lewis C. ;

Blenis, John .

MOLECULAR CELL, 2010, 38 (04) :487-499

← 1 2 3 4 5 6 7 8 9 10 →