mTOR signaling in cellular and organismal energetics

被引：234

作者：

Albert, Verena ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2015年 / 33卷

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

NOVO PYRIMIDINE SYNTHESIS; SKELETAL-MUSCLE; COMPLEX; MAMMALIAN TARGET; LIPID-METABOLISM; GROWTH-CONTROL; TRANSLATION INITIATION; GLUCOSE-HOMEOSTASIS; APPETITE REGULATION; PROTEIN-SYNTHESIS;

D O I：

10.1016/j.ceb.2014.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.

引用

收藏

页码：55 / 66

页数：12

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