Heart Regeneration in the Mexican Cavefish

被引：78

作者：

Stockdale, William T. ^{[1
]}

Lemieux, Madeleine E. ^{[2
]}

Killen, Abigail C. ^{[1
]}

Zhao, Juanjuan ^{[1
]}

Hu, Zhilian ^{[1
]}

Riepsaame, Joey ^{[3
]}

Hamilton, Noemie ^{[4
]}

Kudoh, Tetsuhiro ^{[5
]}

Riley, Paul R. ^{[1
]}

van Aerle, Ronny ^{[6
]}

Yamamoto, Yoshiyuki ^{[4
]}

Mommersteeg, Mathilda T. M. ^{[1
,4
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, South Parks Rd, Oxford OX1 3PT, England

[2] Bioinfo, Plantagenet, ON K0B 1L0, Canada

[3] Univ Oxford, Sir William Dunn Sch Pathol, Genome Engn Oxford, South Parks Rd, Oxford OX1 3RE, England

[4] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

[5] Univ Exeter, Coll Life & Environm Sci, Biosci, Geoffrey Pope Bldg,Stocker Rd, Exeter EX4 4QD, Devon, England

[6] Ctr Environm Fisheries & Aquaculture Sci Cefas, Weymouth DT4 8UB, Dorset, England

来源：

CELL REPORTS | 2018年 / 25卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

LEUCINE-RICH REPEAT; RNA-SEQ DATA; EXPRESSION; ZEBRAFISH; LRRC10; GENES; ADAPTATION; EVOLUTION; ALIGNMENT; SURVIVAL;

D O I：

10.1016/j.celrep.2018.10.072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachon cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at similar levels in both surface fish and Pachon 1 week after injury. However, in Pachon, this peak coincides with a strong scarring and immune response, and ultimately, cavefish cardiomyocytes fail to replace the scar. We identified lrrc10 to be upregulated in surface fish compared with Pachon after injury. Similar to cavefish, knockout of lrrc10 in zebrafish impairs heart regeneration without affecting wound cardiomyocyte proliferation. Furthermore, using quantitative trait locus (QTL) analysis, we have linked the degree of heart regeneration to three loci in the genome, identifying candidate genes fundamental to the difference between scarring and regeneration. Our study provides evidence that successful heart regeneration entails a delicate interplay between cardiomyocyte proliferation and scarring.

引用

页码：1997 / +

页数：18

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