PI 3-kinase: A pivotal pathway in T-cell activation?

被引：162
|
作者：
Ward, SG
June, CH
Olive, D
机构：
[1] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20889
[2] USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889
[3] INSERM U119,F-13009 MARSEILLE,FRANCE
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0167-5699(96)80618-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coupling and/or activation of phosphoinositide 3-kinase (PI 3-kinase) commonly occurs following the triggering of T-cell surface molecules postulated to modulate early events in T-cell activation (e.g. CD28). Recent studies have revealed important and conflicting data as to the role of PI 3-kinase in T-cell costimulation following CD28 ligation. Here, Stephen Wara and colleagues integrate the available data and propose a role for PI 3-kinase in T-cell activation and costimulation.
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页码：187 / 197
页数：11
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