PI 3-kinase: A pivotal pathway in T-cell activation?

被引：162
作者：
Ward, SG
June, CH
Olive, D
机构：
[1] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20889
[2] USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889
[3] INSERM U119,F-13009 MARSEILLE,FRANCE
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0167-5699(96)80618-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coupling and/or activation of phosphoinositide 3-kinase (PI 3-kinase) commonly occurs following the triggering of T-cell surface molecules postulated to modulate early events in T-cell activation (e.g. CD28). Recent studies have revealed important and conflicting data as to the role of PI 3-kinase in T-cell costimulation following CD28 ligation. Here, Stephen Wara and colleagues integrate the available data and propose a role for PI 3-kinase in T-cell activation and costimulation.
引用
收藏
页码：187 / 197
页数：11
相关论文
共 116 条
[31]  
GUINAN EC, 1994, BLOOD, V84, P3261
[32]   CERAMIDE - AN INTRACELLULAR SIGNAL FOR APOPTOSIS [J].
HANNUN, YA ;
OBEID, LM .
TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (02) :73-77
[33]  
HARTLEY KO, 1995, CELL, V82, P848
[34]  
HE TC, 1993, BLOOD, V82, P3530
[35]   RAS-DEPENDENT INDUCTION OF CELLULAR-RESPONSES BY CONSTITUTIVELY ACTIVE PHOSPHATIDYLINOSITOL-3 KINASE [J].
HU, QJ ;
KLIPPEL, A ;
MUSLIN, AJ ;
FANTL, WJ ;
WILLIAMS, LT .
SCIENCE, 1995, 268 (5207) :100-102
[36]   PHORBOL ESTER TREATMENT INHIBITS PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION BY, AND ASSOCIATION WITH, CD28, A T-LYMPHOCYTE SURFACE-RECEPTOR [J].
HUTCHCROFT, JE ;
FRANKLIN, DP ;
TSAI, B ;
HARRISONFINDIK, D ;
VARTICOVSKI, L ;
BIERER, BE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) :8808-8812
[37]   T-CELL PROLIFERATION INVOLVING THE CD28 PATHWAY IS ASSOCIATED WITH CYCLOSPORINE-RESISTANT INTERLEUKIN-2 GENE-EXPRESSION [J].
JUNE, CH ;
LEDBETTER, JA ;
GILLESPIE, MM ;
LINDSTEN, T ;
THOMPSON, CB .
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (12) :4472-4481
[38]   THE B7 AND CD28 RECEPTOR FAMILIES [J].
JUNE, CH ;
BLUESTONE, JA ;
NADLER, LM ;
THOMPSON, CB .
IMMUNOLOGY TODAY, 1994, 15 (07) :321-331
[39]   PHOSPHATIDYLINOSITOL 3-KINASE [J].
KAPELLER, R ;
CANTLEY, LC .
BIOESSAYS, 1994, 16 (08) :565-576
[40]   TRANSCRIPTIONAL CONTROL BY PROTEIN-PHOSPHORYLATION - SIGNAL TRANSMISSION FROM THE CELL-SURFACE TO THE NUCLEUS [J].
KARIN, M ;
HUNTER, T .
CURRENT BIOLOGY, 1995, 5 (07) :747-757
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