PI 3-kinase: A pivotal pathway in T-cell activation?

被引：162

作者：

Ward, SG

June, CH

Olive, D

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20889

[2] USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889

[3] INSERM U119,F-13009 MARSEILLE,FRANCE

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0167-5699(96)80618-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coupling and/or activation of phosphoinositide 3-kinase (PI 3-kinase) commonly occurs following the triggering of T-cell surface molecules postulated to modulate early events in T-cell activation (e.g. CD28). Recent studies have revealed important and conflicting data as to the role of PI 3-kinase in T-cell costimulation following CD28 ligation. Here, Stephen Wara and colleagues integrate the available data and propose a role for PI 3-kinase in T-cell activation and costimulation.

引用

页码：187 / 197

页数：11

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