A role of Ca2+/calmodulin-dependent protein kinase II: In the induction of long-term potentiation in hippocampal CA1 area

被引：16
作者：
Miyamoto, E
Fukunaga, K
机构：
[1] Department of Pharmacology, Kumamoto Univ. School of Medicine
来源：
NEUROSCIENCE RESEARCH | 1996年 / 24卷 / 02期
关键词：
long-term potentiation; hippocampus; glutamate receptor; NMDA; CA1 pyramidal cells; CaM kinase II; Ca2+-influx;
D O I：
10.1016/0168-0102(95)00991-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+-influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+-dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.
引用
收藏
页码：117 / 122
页数：6
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