A role of Ca2+/calmodulin-dependent protein kinase II: In the induction of long-term potentiation in hippocampal CA1 area

被引：16

作者：

Miyamoto, E

Fukunaga, K

机构：

[1] Department of Pharmacology, Kumamoto Univ. School of Medicine

来源：

NEUROSCIENCE RESEARCH | 1996年 / 24卷 / 02期

关键词：

long-term potentiation; hippocampus; glutamate receptor; NMDA; CA1 pyramidal cells; CaM kinase II; Ca2+-influx;

D O I：

10.1016/0168-0102(95)00991-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+-influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+-dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.

引用

页码：117 / 122

页数：6

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