Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

被引：17
|
作者：
Levin, JI
Gu, YS
Nelson, FC
Zask, A
DiJoseph, JF
Sharr, MA
Sung, A
Jin, GX
Cowling, R
Chanda, P
Cosmi, S
Hsiao, CL
Edris, W
Wilhelm, J
Killar, LM
Skotnicki, JS
机构：
[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA
[2] Wyeth Ayerst Res, Princeton, NJ 08543 USA
[3] Wyeth Ayerst Res, Cambridge, MA 02140 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(00)00644-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. (C) 2001 Elsevier Science Ltd. hll rights reserved.
引用
收藏
页码：239 / 242
页数：4
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