Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

被引：17
|
作者：
Levin, JI
Gu, YS
Nelson, FC
Zask, A
DiJoseph, JF
Sharr, MA
Sung, A
Jin, GX
Cowling, R
Chanda, P
Cosmi, S
Hsiao, CL
Edris, W
Wilhelm, J
Killar, LM
Skotnicki, JS
机构：
[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA
[2] Wyeth Ayerst Res, Princeton, NJ 08543 USA
[3] Wyeth Ayerst Res, Cambridge, MA 02140 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期
关键词：
D O I：
10.1016/S0960-894X(00)00644-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. (C) 2001 Elsevier Science Ltd. hll rights reserved.
引用
收藏
页码：239 / 242
页数：4
相关论文
共 50 条
  • [31] Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases
    Bode, W
    Maskos, K
    BIOLOGICAL CHEMISTRY, 2003, 384 (06) : 863 - 872
  • [32] Expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in malignant lymphoma
    Lee, AW
    Lee, AH
    Lee, KY
    Kang, CS
    Shim, SI
    Kim, BK
    MODERN PATHOLOGY, 2002, 15 (01) : 250A - 250A
  • [33] Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases - Warner-Lambert Company: W09918079
    不详
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2000, 10 (01) : 111 - 115
  • [34] Expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in malignant lymphoma
    Lee, AW
    Lee, AH
    Lee, KY
    Kang, CS
    Shim, SI
    Kim, BK
    LABORATORY INVESTIGATION, 2002, 82 (01) : 250A - 250A
  • [35] Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases
    Klaus Maskos
    Wolfram Bode
    Molecular Biotechnology, 2003, 25 : 241 - 266
  • [36] Balance between Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
    Yalcinkaya, Emre
    Celik, Murat
    CARDIOLOGY, 2014, 128 (04) : 316 - 316
  • [37] Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases
    Maskos, K
    Bode, W
    MOLECULAR BIOTECHNOLOGY, 2003, 25 (03) : 241 - 266
  • [38] Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function
    McIntush, EW
    Smith, MF
    REVIEWS OF REPRODUCTION, 1998, 3 (01): : 23 - 30
  • [39] MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF METALLOPROTEINASES IN HUMAN GLIOMAS
    NAKANO, A
    TANI, E
    MIYAZAKI, K
    YAMAMOTO, Y
    FURUYAMA, JI
    JOURNAL OF NEUROSURGERY, 1995, 83 (02) : 298 - 307
  • [40] Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases
    Pikul, S
    Ohler, NE
    Ciszewski, G
    Laufersweiler, MC
    Almstead, NG
    De, B
    Natchus, MG
    Hsieh, LC
    Janusz, MJ
    Peng, SX
    Branch, TM
    King, SL
    Taiwo, YO
    Mieling, GE
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (16) : 2499 - 2502
12345