Transformative Effects of Higher Magnetic Field in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

被引：9

作者：

Karabacak, N. Murat ^{[1
,2
]}

Easterling, Michael L. ^{[3
]}

Agar, Nathalie Y. R. ^{[4
]}

Agar, Jeffrey N. ^{[1
,2
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

[2] Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02454 USA

[3] Bruker Daltonics Inc, Billerica, MA USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurosurg, Boston, MA 02115 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2010年 / 21卷 / 07期

基金：

美国国家卫生研究院;

关键词：

SIGNAL-TO-NOISE; RESOLUTION; CHARGE; SPECTROSCOPY; RATIO; CELL;

D O I：

10.1016/j.jasms.2010.03.033

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship of magnetic field strength and Fourier transform ion cyclotron resonance mass spectrometry performance was tested using three instruments with the same design but different fields of 4.7, 7, and 9.4 tesla. We found that the theoretically predicted "transformative" effects of magnetic field are indeed observed experimentally. The most striking effects were that mass accuracy demonstrated similar to second to third order improvement with the magnetic field, depending upon the charge state of the analyte, and that peak splitting, which prohibited automated data analysis at 4.7 T, was not observed at 9.4 T. (J Am Soc Mass Spectrom 2010, 21, 1218-1222) (C) 2010 American Society for Mass Spectrometry

引用

页码：1218 / 1222

页数：5

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