Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence

被引:190
作者
Kalkbrenner, Amy E. [1 ]
Schmidt, Rebecca J. [2 ,3 ]
Penlesky, Annie C. [1 ]
机构
[1] Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA
[2] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA
[3] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA 95817 USA
关键词
THIMEROSAL-CONTAINING VACCINES; TOBACCO-SMOKE EXPOSURE; PERINATAL RISK-FACTORS; PERSISTENT ORGANIC POLLUTANTS; HAZARDOUS AIR-POLLUTANTS; PRENATAL EXPOSURE; NEURODEVELOPMENTAL DISORDERS; OCCUPATIONAL EXPOSURES; MATERNAL SMOKING; ORGANOPHOSPHATE PESTICIDES;
D O I
10.1016/j.cppeds.2014.06.001
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In the past decade, the number of epidemiological publications addressing environmental chemical exposures and autism has grown tremendously. These studies are important because it is now understood that environmental factors play a larger role in causing autism than previously thought and because they address modifiable risk factors that may open up avenues for the primary prevention of the disability associated with autism. In this review, we covered studies of autism and estimates of exposure to tobacco, air pollutants, volatile organic compounds and solvents, metals (from air, occupation, diet, dental amalgams, and thimerosal-containing vaccines), pesticides, and organic endocrine-disrupting compounds such as flame retardants, non-stick chemicals, phthalates, and bisphenol A. We included studies that had individual-level data on autism, exposure measures pertaining to pregnancy or the 1st year of life, valid comparison groups, control for confounders, and adequate sample sizes. Despite the inherent error in the measurement of many of these environmental exposures, which is likely to attenuate observed associations, some environmental exposures showed associations with autism, especially traffic-related air pollutants, some metals, and several pesticides, with suggestive trends for some volatile organic compounds (e.g., methylene chloride, trichloroethylene, and styrene) and phthalates. Whether any of these play a causal role requires further study. Given the limited scope of these publications, other environmental chemicals cannot be ruled out, but have not yet been adequately studied. Future research that addresses these and additional environmental chemicals, including their most common routes of exposures, with accurate exposure measurement pertaining to several developmental windows, is essential to guide efforts for the prevention of the neurodevelopmental damage that manifests in autism symptoms.
引用
收藏
页码:277 / 318
页数:42
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